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Japanese journal of pharmacology

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The role of capsaicin-sensitive afferent nerves in protective effect of capsaicin against absolute ethanol-induced gastric lesions in rats.

Published:1 February 1991 DOI: 10.1254/jjp.55.279 PMID: 2067143
M Uchida, S Yano, K Watanabe

Abstract

The role of capsaicin-sensitive afferent nerves in gastroprotection by capsaicin was investigated in the absolute ethanol-induced gastric lesion model in rats. Capsaicin (0.1 and 0.5 mg/kg, p.o.) inhibited the lesion formation dose-dependently. The protective effect of capsaicin was attenuated by indomethacin-pretreatment and disappeared in capsaicin-sensitive nerve degenerated rats. Capsaicin did not induce the distension of gastric mucosal folds. These results suggested that stimulation of capsaicin-sensitive afferent nerves by capsaicin would enhance the prostaglandin formation, leading to an inhibition of gastric lesions.

Substances (4)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Ethanol 64-17-5 C2H6O 804 suppliers $10.00-$17310.00
Capsaicin 404-86-4 C18H27NO3 735 suppliers $28.00-$1963.50
Indometacin 53-86-1 C19H16ClNO4 679 suppliers $18.65-$1700.00
Prostaglandin E2 363-24-6 C20H32O5 331 suppliers $26.00-$4800.00

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