天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

ChemicalBook >> journal list >> Toxicology letters >>article
Toxicology letters

Toxicology letters

IF: 2.89
Download PDF

The covalent interaction of 1,4-dibromobenzene with rat and mouse nucleic acids: in vivo and in vitro studies

Published:1 December 1990 DOI: 10.1016/0378-4274(90)90174-K PMID: 1701931
Annamaria Colacci , Silvana Bartoli , Bruna Bonora , Mario Mazzullo , Alessandra Niero , Paolo Perocco , Paola Silingardi , Sandro Grilli

Abstract

1,4-Dibromobenzene (1,4-DBB) was covalently bound to DNA from liver, kidney, lung and stomach of mice after intraperitoneal administration. The covalent binding index (CBI) value (23 in mouse liver) was typical of weak initiators. On the contrary, no interaction with DNA from rat organs was observed (CBI detection limit: 1.3–2.6). The in vitro interaction of 1,4-DBB with calf thymus DNA was mediated mainly by microsomes, especially those from liver of both species and from mouse lung. Mouse subcellular fractions were more active then rat subcellular fractions. Unlike liver cytosol, subcellular cytosolic fractions from lung, kidney and stomach were capable of bioactivating 1,4-DBB, although to a lesser extent than liver microsomes. Both cytochrome P-450 and GSH-transferases are involved in 1,4-DBB bioactivation.

Substances (4)

Related products
Procduct Name CAS Molecular Formula Supplier Price
1,4-Dibromobenzene 106-37-6 C6H4Br2 579 suppliers $9.00-$1025.00
DEOXYRIBONUCLEIC ACID 100403-24-5 Null 175 suppliers $60.20-$459.56
DEOXYRIBONUCLEIC ACID SODIUM SALT 73049-39-5 NULL 127 suppliers $60.20-$1910.00
cytochrome P-450 2A7 10 suppliers Inquiry

Similar articles

IF:3.8

Salidroside inhibits the growth of human breast cancer in vitro and in vivo.

Oncology reports Gang Zhao, Aiping Shi,etc Published: 1 May 2015
IF:3.3

Effect of 1,4-dibromobenzene and 1,2,4-tribromobenzene on xenobiotic metabolism

Toxicology and applied pharmacology Gary P. Carlson , Robert G. Tardiff,etc Published: 1 October 1977
IF:5.7

4-Methylumbelliferone Inhibits Angiogenesis in Vitro and in Vivo

Journal of Agricultural and Food Chemistry Javier A. García-Vilas, Ana R. Quesada,etc Published: 12 April 2013