提取來(lái)源：豆科植物蒙古黃芪 Astragalus membranaceus （Fisch.）Bge. var.mongholicus （Bge）Hsiao或 Astragalus membranaceus （Fisch.）Bge.的干燥根。
主要應(yīng)用：環(huán)黃芪醇（Cycloastragenol）是從豆科植物蒙古黃芪Astragalus membranaceus(Fisch．)Bge．var．mongholicus(I Hsiao或膜莢黃芪Astragalus mernbranaceus(Fiseh．)Bge．的干燥根中直接提取分離或由黃芪甲苷（Astragaloside Ⅳ）的水解得到，具有增強(qiáng)機(jī)體免疫力、清除自由基、保護(hù)心肌細(xì)胞、增強(qiáng)心肌活力，減輕心肌缺血、抗心力衰竭等作用。其機(jī)制是通過(guò)抑制磷酸二酯酶的活性，使環(huán)磷腺苷(cAMP)分解減少，心肌細(xì)胞中 cAMP濃度增加，促進(jìn)肌漿網(wǎng)內(nèi)鈣離子的釋放，從而使心肌細(xì)胞的興奮-收縮偶聯(lián)活動(dòng)加。黃芪還能改善血液流變學(xué)，降低血液粘滯度，減輕心臟負(fù)荷。在中國(guó)臨床應(yīng)用多年的中成藥“黃芪口服液”、中藥注射劑“黃芪注射液”中的主要成分即是Astragaloside Ⅳ，“黃芪注射液”主要用于治療病毒性心肌炎、心功能不全及肝炎等疾病。“黃芪口服液”主要用于治療病毒性肝炎、和提高機(jī)體免疫力、抗疲勞等。
最近，黃芪甲苷和環(huán)黃芪醇的作用機(jī)理研究已有了突破性的進(jìn)展。 特別是美國(guó)Geron 生物技術(shù)公司的研究發(fā)現(xiàn)了黃芪甲苷及其苷原環(huán)黃芪醇主要是通過(guò)激活Telomerase而發(fā)揮其生物學(xué)作用，對(duì)以黃芪甲苷和環(huán)黃芪醇為基礎(chǔ)的新藥和新保健品的研究開(kāi)發(fā)起到了積極的推動(dòng)作用。
Product name: Cycloastragenol
Botanical source: Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge) Hsiao or Astragalus menbranaceus (Fisch.) Bge.
Specification: 90% 98%
Test Method: HPLC-ELSD
CAS No.: 84605-18-5
Molecular Formula: C30H50O5
Molecular Weight: 490.72
Function:
Cycloastragenol is a sapogenin found in or derived from Astragalus membranaceus. It seems to moderately increase telomerase activity and proliferative capacity in both CD4 and CD8 T cells in in vitro experiments. Cycloastragenol is extracted and purified from the roots of Astragalus membranaceus, being claimed to stimulate immune system, to improve cardiovascular health, and to repair DNA.
Cycloastragenol has a similar chemical structure to that of the Astragaloside IV molecule, but it is smaller and significantly more bioavailable, enabling lower doses to be taken. It is already used as an immunostimulant because of its ability to increase T lymphocyte proliferation. However, it is its exceptional anti-aging properties that are of increasing interest to the scientific community. Cycloastragenol stimulates the repair of DNA damage by activating telomerase, a nucleoprotein enzyme which catalyses synthesis and growth of telomeric DNA. Telomeres are made of thin filaments and are found at the tips of chromosomes. Maintaining their stability enables cells to avoid replicative senescence and indefinite proliferation beyond the ‘Hayflick limit’. Telomeres shorten with each cycle of cell division, or when subjected to oxidative stress. Until now, this has been an unavoidable mechanism of aging.
Storage: Store in sealed containers at cool & dry place. Protect from light, moisture and pest infestation
Shelf life: 2 years when properly stored.
Packing: 1KG/Aluminum foil.