Product Name:L-Biopterin(NSC 339699;6-Biopterin)
Appearance:Colorless to pale yellow powder
Purity(HPLC): min98.0%
Product Name: L-Biopterin; 6-Biopterin
CAS No.: 22150-76-1
Synonyms: 6-Biopterin,NSC 339699, L-erythro-Biopterin; (1'R,2'S)-Biopterin; 2-Amino-4-hydroxy-6-(1,2-dihydroxypropyl)pteridine
Chemical Name: 2-amino-6-(1,2-dihydroxypropyl)-1H-pteridin-4-one
Molecular Formula: C9H11N5O3
Molecular Weight: 237.22
Product Description:
L-Biopterin is the oxidized form of tetrahydro-L-biopterin (BH4), a nitric oxide synthase (NOS) cofactor. L-Biopterin can be reduced to BH4 via thioredoxin reductase followed by dihydropteridine reductase or reduced glutathione. It is extremely toxic to human melanocytes in culture (IC50 = 0.2 µM after 48 hrs). L-Biopterin is rarely found under physiological conditions except in the epidermis of patients with the depigmentation disorder Vitiligo.
L-Biopterin is an important cofactor in the production of many essential neurotransmitters, such as dopamine, seratonin and epinephrine, and plays an important role in the production of nitric oxide in the body. It is produced as an oxidation product by the melanogenesis regulating cofactor (6R)5,6,7,8 tetrahydrobiopterin (6-BH4). L-Biopterin has been shown to be cytotoxic to melanocytes in vitro, and may be a useful noninvasive biomarker.
Applications: A pteridine widely distributed in nature; naturally occurring as the L-erythro-form. Considered as a growth factor for some insects. Fluoresces with a blue color in alkaline solution. A cofactor in the production of many neurotransmitters and nitric oxide.
6-Biopterin is an oxidation product from the melanogenesis regulating cofactor (6R)5,6,7,8 tetrahydrobiopterin (6-BH4). In vitro, 6-Biopterin is cytotoxic to melanocytes. However, in vivo, 6-Biopterin is rapidly and sequentially reduced back to 6-GH4 via q-BH2. Recent studies suggest that 6-Biopterin among other pteridines may be a useful non-invasive biomarker for cancer.
Synonyms: NSC 339699; 6-Biopterin; L-Erythro-biopterin; (1'R,2'S)-Biopterin;2-Amino-4-hydroxy-6-(1,2-dihydroxypropyl)pteridine;2-amino-6-(1,2-dihydroxypropyl)pteridin-4(1H)-one;2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]pteridin-4(1H)-one;2-amino-7-(1,2-dihydroxypropyl)pteridin-4(1H)-one
CAS No: 22150-76-1
Molecular Formula: C9H11N5O3
Molecular Weight: 237.22
Appearance: Colorless to pale yellow powder
Storage: Store in cool dark place keep away from the sunshine light.
Biochemical functions: Biopterin has two isomers (D- and L-biopterin). We sell only L-Biopterin. The hydrogenated forms of biopterin i.e. dihydrobiopterin and tetrahydrobiopterin are involved in many important biochemical functions in the human body, among which are the hydroxylation of tyrosine, phenylalanine and tryptophan.
Solubility: Biopterin is very slightly soluble in water. The solubility of biopterin is about 0.01 g per 100 g of water (22°C ). Concentrated solutions of biopterin may be prepared using 0.05M NaOH. Ultrasonication may be used to improve dissolution.
Analytical methods:
HPLC conditions: Column: Waters Spherisorb S5 ODS1
Eluant: 10mM Na2HPO4 PH 6-methanol, (19:1)
Flow rate: 1ml/min
Wavelength: 254nm
Solution: 2mg/ml 0.05 M NaOH
TLC conditions: Stationary phase: cellulose
Eluant: water
Specifications: Purity: HPLC >98.0%
TLC one blue fluorescent spot at 366nm
Stability: Biopterin is light sensitive. Biopterin contains half a mole of water. It can be stored for several years, dry, in tightly closed bottle coloured , at - 20°C or colder.
Storage: Keep the powder dry in tightly closed bottle coloured , at - 20°C . Biopterin can be transported without the use of dry ice. In tightly closed bottle, wrapped in aluminium foil, it is stable at ambient temperature for several months.
Uses: Biopterin is an important standard for analytical work involving tetrahydrobiopterin and dihydrobiopterin. It is not suitable for the addition to nutritional supplements .
Safety information: Biopterin is known to be safe and there are no special precautions required in handling this product.
Remarks: The information in this publication is based on our current knowledge and experience. It does not relieve users or processors from carrying out their own precautions and tests.
關(guān)鍵字： L-Biopterin;NSC 339699
凱立德生物醫(yī)藥是一家專(zhuān)門(mén)從事化學(xué)定制合成，醫(yī)藥中間體以及新藥研發(fā)的外向型企業(yè)。公司堅(jiān)持以科技創(chuàng)新為動(dòng)力，以市場(chǎng)需求為導(dǎo)向，產(chǎn)品涵蓋醫(yī)藥原料，醫(yī)藥中間體，天然產(chǎn)物,手性化合物，藥物研究試劑等。同時(shí)致力于為國(guó)內(nèi)外知名藥企，科研機(jī)構(gòu)及高校提供新型和高附加值的醫(yī)藥原料、醫(yī)藥中間體及天然產(chǎn)物的訂制合成服務(wù)。
公司自成立以來(lái)，始終堅(jiān)持客戶(hù)至上的經(jīng)營(yíng)理念，不斷進(jìn)取，贏得了國(guó)內(nèi)外客戶(hù)的好評(píng)與信任，并與其建立了長(zhǎng)期穩(wěn)定的業(yè)務(wù)關(guān)系。公司將一如既往的以嚴(yán)格的質(zhì)量管理體系，穩(wěn)定的產(chǎn)品質(zhì)量為客戶(hù)提供優(yōu)質(zhì)的產(chǎn)品和服務(wù)。
ChemLeader Biomedical is a professional manufacturer and supplier of New Advanced Pharmaceutical Intermediates, Active Pharmaceutical Ingredients (API) & Drug Impurities.
ChemLeader mainly manufactures & supplies pharmaceutical Intermediates, API & Drug Impurities, Nutri-Health Supplements, and Cosmetic Ingredients.