Product Name: Cabazitaxel(XRP-6258); Cabazitaxel; 7β,10β-Dimethoxydocetaxel; TXD 258; XRP 6258; XRP6258; RPR-116258A; Taxoid XRP6258; TXD-258; XRP-6258; RPR-116258; Jevtana CAS No.:183133-96-2 Molecular Formula: C45H57NO14 Molecular Weight: 835.93 Appearance:White to off white crystalline powder Purity(HPLC):NLT99.0% Biological Activity: Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance (MDR), P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors. In addition, cabazitaxel penetrates the blood-brain barrier (BBB).
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