CD37產(chǎn)品信息

英文名稱：Leukocyte antigen CD37

中文名稱：白細(xì)胞抗原CD37

靶點(diǎn)別稱：CD37，TSPAN26，Tetraspanin-26

物種：Human

標(biāo)簽：His Tag/Fc Tag

屬性：Protein

標(biāo)記：FITC Labeled/Unconjugated

表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）

Human CD37, Fc Tag (CD7-H525a) is expressed from human 293 cells (HEK293). It contains AA Arg 112 - Asn 241 (Accession # P11049-1).

Predicted N-terminus: Arg 112

蛋白結(jié)構(gòu)（Molecular Characterization）

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 41.3 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

白細(xì)胞抗原CD37（CD37）也被稱為Tetraspanin-26（Tspan-26）和TSPAN26，TSPAN26是跨膜4超家族或Tetraspanin家族的成員。這些成員中的大多數(shù)是細(xì)胞表面蛋白，其特征是存在四個(gè)疏水結(jié)構(gòu)域。CD37基因編碼的蛋白質(zhì)介導(dǎo)信號(hào)轉(zhuǎn)導(dǎo)事件，這些事件在細(xì)胞發(fā)育、活化、生長(zhǎng)和運(yùn)動(dòng)的調(diào)節(jié)中發(fā)揮作用。CD37是一種已知與整合素和其他跨膜4超家族蛋白復(fù)合的細(xì)胞表面糖蛋白。CD37可能在T細(xì)胞與B細(xì)胞的相互作用中發(fā)揮作用。