優(yōu)立替尼|T7005

價格	￥335	￥477	￥822
包裝	1mg	2mg	5mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-12-02

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產(chǎn)品詳情

中文名稱:優(yōu)立替尼	英文名稱:Ulixertinib
CAS:869886-67-9	品牌: TargetMol
產(chǎn)地: 美國	保存條件: store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 99.95%	產(chǎn)品類別: 抑制劑
貨號: T7005

Product Introduction

Bioactivity

名稱	Ulixertinib
描述	Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.
細胞實驗	A375 cells are cultured in cell media composed of DMEM, 10% (v/v) Foetal Calf Serum and 1% (v/v) L-Glutamine. After harvesting, cells are dispensed into black, 384-well Costar plates to give 200 cells per well in a total volume of 40 μL cell media, and are incubated overnight at 37°C, 90% relative humidity and 5% CO2 in a rotating incubator. Test compounds and reference controls are dosed directly into the cell plates, into the inner 308 wells, using a Labcyte Echo 555 acoustic dispenser. The cells are dosed over a 12 point range from 30 μM down to 0.03 nM in order to calculate compound IC50s, with a total DMSO concentration in the assay of 0.3%. The cell plates are then incubated for 72 hours at 37°C. Cells were fixed and stained by the addition of 20 μL 12% formaldehyde in PBS/A (4% final concentration) and 1:2000 dilution of Hoechst 33342, with a 30 minute room temperature incubation, and then washed with PBS/A. A cell count is performed on the stained cell plates using a Cellomics ArrayScanTM VTI imaging platform. A Day 0 cell plate is also fixed, stained and read to generate a cell count baseline for determining compound cytotoxic effects as well as anti-proliferative effects.(Only for Reference)
激酶實驗	ERK2 Rapidfire Mass Spectrometry Inhibition of Catalysis Assay: MEK U911-activated ERK2 protein is expressed and purified in-house. Enzyme and substrate solutions are made up in assay buffer consisting of 50 mM Tris (pH 7.5), 10 mM MgCl2, 0.1 mM EGTA, 10 mM DTT and 0.01% (v/v) CHAPS. 1.2 nM ERK2 protein is prepared in assay buffer and 10 μL is dispensed into each well of a polypropylene, 384-well plate containing test and reference control compounds. The compound plates had previously been dosed with a 12 point range from 100 μM down to 0.1 nM in order to calculate compound IC50s, with a total DMSO concentration in the assay of 1%. Following a 20 minute pre-incubation of enzyme and compound at room temperature, 10 μL of substrate solution is added consisting of 16 μM Erktide (IPTTPITTTYFFFK) and 120 μM ATP (measured Km) in assay buffer. The reaction is allowed to progress for 20 minutes at room temperature before being quenched by the addition of 80 μl 1% (v/v) formic acid. The assay plates are then run on the RapidFire Mass Spectrometry platform to measure substrate (unphosphorylated Erktide) and product (phosphorylated Erktide) levels.
體外活性	在含有b-RAFV600E突變的A375黑色素瘤細胞株中，Ulixertinib分別以IC50為4.1/0.14 μM降低磷酸化ERK2（pERK）和下游激酶RSK（pRSK）的水平。同時，Ulixertinib以IC50為180 nM抑制A375細胞的增殖。[1]
存儲條件	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 70 mg/mL (161.54 mM) 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 8 mg/mL (18.46 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. Ethanol : 12 mg/mL (27.7 mM)
關鍵字	ERK \| VRT 752271 \| inhibit \| BVD 523 \| Ulixertinib \| VRT-752271 \| BVD523 \| Inhibitor \| Extracellular signal regulated kinases
相關產(chǎn)品	Lidocaine hydrochloride \| Astragaloside IV \| Lidocaine \| ROCK-IN-5 \| Honokiol \| Notoginsenoside R1 \| Tauroursodeoxycholate \| Olomoucine \| Selumetinib \| Allicin \| Ro-3306 \| TBHQ
相關庫	抑制劑庫 \| 抗癌活性化合物庫 \| 經(jīng)典已知活性庫 \| 已知活性化合物庫 \| 抗衰老化合物庫 \| 藥物功能重定位化合物庫 \| 疼痛相關化合物庫 \| 抗癌臨床化合物庫 \| 抗癌藥物庫

關鍵字：優(yōu)立替尼|||VRT752271|||BVD-523|TargetMol

公司簡介

上海陶術(shù)生物科技有限公司為美國Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國波士頓、德國慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學研究的科學家提供優(yōu)質(zhì)的產(chǎn)品和專業(yè)的服務。公司下設篩選事業(yè)部，化學事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實體化合物分子供應；從商業(yè)化產(chǎn)品銷售到個性化定制合成；從對明確靶點的分子篩選到對明確分子的多靶點篩選，從高通量篩選到化學結(jié)構(gòu)優(yōu)化，我們都可以滿足您的科研用品及技術(shù)服務的需求。經(jīng)過在中國市場五年的精心耕耘，我們已成為篩選化合物領域優(yōu)秀的供應商，為超過五百家學校和各類企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （12年）	注冊資本	566.2651萬人民幣
員工人數(shù)	100-500人	年營業(yè)額	￥ 1億以上
主營行業(yè)	化學試劑,生物活性小分子	經(jīng)營模式	貿(mào)易,試劑,定制,服務

TargetMol中國（陶術(shù)生物）

VIP 12年

公司成立：12年
注冊資本：566.2651萬人民幣
企業(yè)類型：有限責任公司(自然人投資或控股)
主營產(chǎn)品：小分子抑制劑，藥物篩選化合物庫，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場三路28號4樓

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優(yōu)立替尼|T7005相關廠家報價

產(chǎn)品名稱	價格		公司名稱	報價日期
ERK1，ERK2抑制劑(VRT752271)	詢價	VIP6年	上海澤葉生物科技有限公司	2024-12-26
869886-67-9 優(yōu)立替尼	詢價	VIP1年	陜西西化化學工業(yè)有限公司	2024-12-17
優(yōu)立替尼VRT752271—869886-67-9	￥478	VIP3年	湖北魏氏化學試劑股份有限公司	2024-12-11
aladdin 阿拉丁 U409233 Ulixertinib (BVD-523) 869886-67-9 10mM in DMSO	￥888.90	VIP1年	上海阿拉丁生化科技股份有限公司	2024-11-29
VRT752271	￥2000		上海瑯迪信息科技中心	2024-10-24
Ulixertinib (BVD-523,VRT752271)	詢價		南京百鑫德諾生物科技有限公司	2024-09-26
4-[5-氯-2-[(1-甲基乙基)氨基]-4-吡啶基]-N-[(1S)-1-(3-氯苯基)-2-羥基乙基]-1H-吡咯-2-甲酰胺	￥2000	VIP8年	上海珂臻醫(yī)藥科技有限公司	2023-11-11
優(yōu)立替尼	詢價		武漢貝爾卡生物醫(yī)藥有限公司	2023-05-30
優(yōu)立替尼	詢價		匯聚化學（上海）有限公司	2022-02-24
4-[5-氯-2-[(1-甲基乙基)氨基]-4-吡啶基]-N-[(1S)-1-(3-氯苯基)-2-羥基乙基]-1H-吡咯-2-甲酰胺	￥2000	VIP8年	上海珂臻醫(yī)藥科技有限公司	2023-11-11

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