普樂沙福|T1776

價(jià)格	￥163	￥343	￥572
包裝	1mg	5mg	10mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-12-02

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產(chǎn)品詳情

中文名稱:普樂沙福	英文名稱:Plerixafor
CAS:110078-46-1	品牌: TargetMol
產(chǎn)地: 美國	保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: ≥95%	產(chǎn)品類別: 抑制劑
貨號: T1776

Product Introduction

Bioactivity

Name	Plerixafor
Description	Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.
Cell Research	Plerixafor is dissolved in DMSO and then diluted with appropriate medium[2]. U87 mg cells are seeded in 96-well plates at the density of 6×103 cells in 200 μL/well and treated with CXCL12, Plerixafor or with peptide R, as described in the previous "Treatments" section. MTT (5 μg/mL) is added at each time point (24, 48, 72 h) during the final 2 h of treatment. After removing cell medium, 100 μL DMSO are added and optical densities measured at 595 nm with a LT-4000MS Microplate Reader. Measurements are made in triplicates from three independent experiments[2].
Kinase Assay	In vitro biochemical assays against histone acetylases: GSK503 is profiled to assess inhibition against a panel of histone acetylases. GSK503 is dissolved in DMSO and tested in 10-dose IC50 mode with 3-fold serial dilution starting at 100 μM, with a final DMSO concentration of 2%. Anacardic Acid is used as positive control for CBP, GCN5, and pCAF and tested in 10-dose IC50 mode with 3-fold serial dilution starting at 100 μM. Curcumin is used as positive control for KAT5, MYST2/KAT7, MYST4/KAT6B, and p300, and tested in 10-dose IC50 mode with 3-fold serial dilution starting at 100 μM. Reactions are carried out at 3.08 μM Acetyl-CoA. For CBP, GCN5, MYST2/KAT7, pCAF, and p300, the substrate used is histone H3. For KAT5 and MYST4/KAT6B the substrates used are histone H2A and histone H4, respectively.
In vitro	Plerixafor以略優(yōu)于其對CXCR4親和力的效力，抑制了CXCL12介導(dǎo)的趨化作用。[1] Plerixafor還以IC50為651 nM對SDF-1/CXCL12配體結(jié)合產(chǎn)生拮抗作用。對于SDF-1介導(dǎo)的GTP結(jié)合、SDF-1介導(dǎo)的鈣流和SDF-1刺激的趨化作用，Plerixafor的IC50分別為27 nM、572 nM和51 nM。Plerixafor不抑制表達(dá)CXCR3、CCR1、CCR2b、CCR4、CCR5或CCR7的細(xì)胞在其相應(yīng)配體刺激下的鈣流，也不抑制LTB4的受體結(jié)合。Plerixafor本身不在表達(dá)多種GPCRs（包括CXCR4、CCR4和CCR7）的CCRF-CEM細(xì)胞中誘導(dǎo)鈣流。[2]
In vivo	單次局部施用Plerixafor能通過增加細(xì)胞因子產(chǎn)生、動員骨髓EPCs、增強(qiáng)成纖維細(xì)胞和單核細(xì)胞/巨噬細(xì)胞的活性，從而促進(jìn)糖尿病小鼠的傷口愈合，同時(shí)增加血管生成和血管形成。[3] 小鼠連續(xù)五天被給予PBS、IGF1、PDGF、SCF或VEGF，并在第5天給予Plerixafor。與PDGF、SCF和VEGF處理組相比，IGF1加Plerixafor注射的小鼠群體中，克隆的數(shù)量和大小最大。[4]
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	PBS : 1 mg/mL (1.98 mM), Sonication is recommended. Ethanol : 50 mg/mL, Sonication is recommended. DMSO : < 1 mg/mL (insoluble）, Sonication is recommended. H2O : Insoluble
Keywords	JM 3100 \| stream \| inhibit \| multiple \| Inhibitor \| SID-791 \| Human immunodeficiency virus \| Plerixafor \| cancer \| G-CSF \| human \| JM-3100 \| stem \| myeloma \| SID 791 \| cells \| blood \| CXC chemokine receptors \| lymphoma \| AMD3100 \| SID791 \| HIV \| ligand \| AMD 3329 \| AMD3329 \| mobilizer \| CXCR \| peripheral \| AMD-3100
Inhibitors Related	Emtricitabine \| Lamivudine \| Stavudine

關(guān)鍵字：普樂沙福|||JM3100|||AMD-3329|||AMD 3100|TargetMol

公司簡介

上海陶術(shù)生物科技有限公司為美國Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國波士頓、德國慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學(xué)研究的科學(xué)家提供優(yōu)質(zhì)的產(chǎn)品和專業(yè)的服務(wù)。公司下設(shè)篩選事業(yè)部，化學(xué)事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實(shí)體化合物分子供應(yīng)；從商業(yè)化產(chǎn)品銷售到個性化定制合成；從對明確靶點(diǎn)的分子篩選到對明確分子的多靶點(diǎn)篩選，從高通量篩選到化學(xué)結(jié)構(gòu)優(yōu)化，我們都可以滿足您的科研用品及技術(shù)服務(wù)的需求。經(jīng)過在中國市場五年的精心耕耘，我們已成為篩選化合物領(lǐng)域優(yōu)秀的供應(yīng)商，為超過五百家學(xué)校和各類企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （12年）	注冊資本	566.2651萬人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營行業(yè)	化學(xué)試劑,生物活性小分子	經(jīng)營模式	貿(mào)易,試劑,定制,服務(wù)

TargetMol中國（陶術(shù)生物）

VIP 12年

公司成立：12年
注冊資本：566.2651萬人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營產(chǎn)品：小分子抑制劑，藥物篩選化合物庫，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場三路28號4樓

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