司來司他|T6111

價(jià)格	￥179	￥396	￥528
包裝	1mg	5mg	10mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-12-02

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產(chǎn)品詳情

中文名稱:司來司他	英文名稱:Selisistat
CAS:49843-98-3	品牌: TargetMol
產(chǎn)地: 美國	保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 99.79%	產(chǎn)品類別: 抑制劑
貨號(hào): T6111

Product Introduction

Bioactivity

名稱	Selisistat
描述	Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM). Selisistat can be used in the study of neurological disorders such as Huntington's chorea.
細(xì)胞實(shí)驗(yàn)	NCI-H460 cells, MCF-7 cells, U-2 OS cells, or HMEC were plated at 2,000 cells per well in opaque-walled 96-well plates for the viability assay and 800 cells per well in 96-well Cytostar-T scintillating microplates for the proliferation assay. Cells were incubated for 1 day (NCI-H460) or 2 days (MCF-7, U-2 OS, and HMEC) prior to exposure to DNA-damaging agents and deacetylase inhibitors. All experiments were performed in triplicate. For viability assays, cells were treated with the indicated compounds for 48 h. Cell viability was then determined using the Cell Titer-Glo luminescent assay, which measures total ATP levels as an index of cell number. Luminescence was measured on a Luminoskan Ascent. For the proliferation assay, 0.5 μCi/ml of [14C]thymidine was added to the medium immediately after the genotoxins and deacetylase inhibitors. Plates were counted at 48 h (HMEC) or 72 h (NCI-H460, MCF-7, and U-2 OS cells) in a Microbeta liquid scintillation counter. Thymidine incorporated by the cells was detected by proximity to the scintillant in the base of the Cytostar-T tissue culture plate [1].
動(dòng)物實(shí)驗(yàn)	Mice were injected with RSV (RSV) 30mg/kg (4ml/kg) or equivalent volume of DMSO (Vehicle) (4ml/kg) intraperitoneally 18 hours pre-sepsis. This dose of RSV in mice was as per documented literature. In one group of mice, RSV pre-treated mice received EX-527 (10 mg/kg intraperitoneally; 4ml/kg, Vehicle: DMSO) within 10 minutes of cecal ligation and puncture [5].
體外活性	方法：人結(jié)直腸癌細(xì)胞 HCT116 用 0.1% 血清和 Selisistat (1-2 μM) 培養(yǎng) 7 天，檢測細(xì)胞數(shù)量。結(jié)果：當(dāng) HCT116 細(xì)胞在 0.1% 血清中培養(yǎng)時(shí)，添加 Selisistat 導(dǎo)致 7 天后細(xì)胞數(shù)量增加 90%。在生長因子缺乏條件下，SirT1 是細(xì)胞增殖的重要調(diào)節(jié)因子。[1] 方法：人肺癌細(xì)胞 NCI-H460 用 etoposide (20 μM) 和 Selisistat (1 μM) 處理 6 h，使用 Western Blot 檢測靶點(diǎn)蛋白表達(dá)水平。結(jié)果：在用 DNA 損傷劑 etoposide 處理的細(xì)胞中，Selisistat 產(chǎn)生乙?；?p53 的增加。[2]
體內(nèi)活性	方法：為研究對(duì)肺損傷的作用，將 Selisistat (10 mg/kg) 腹腔注射給 Balb/C 小鼠，0.5 h 后注射 LPS 誘導(dǎo)肝損傷。結(jié)果：Selisistat 對(duì) SIRT1 的選擇性抑制可能部分通過抑制 mTOR 來減輕內(nèi)毒素血癥相關(guān)的急性肺損傷。[3] 方法：為研究對(duì)亨廷頓舞蹈癥 (HD) 的作用，將 Selisistat (5-20 mg/kg，0.5% HPMC) 灌胃給藥給 R6/2 小鼠，每天一次，直至死亡。結(jié)果：Selisistat 治療導(dǎo)致接受 20 mg/kg 劑量的小鼠的存活率顯著增加，中位壽命顯著增加了 3 周，在檢查自主運(yùn)動(dòng)活動(dòng)時(shí)也觀察到顯著的改善。[4]
存儲(chǔ)條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1.87 mg/mL (7.52 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. DMSO : 60 mg/mL (241.24 mM) Ethanol : 12.4 mg/mL (50 mM)
關(guān)鍵字	mammalian \| Huntington's \| inhibit \| pathology \| Sirtuin \| Drosophila \| deacetylation \| Selisistat \| SEN-0014196 \| EX 527 \| Inhibitor \| SEN 0014196 \| disease \| EX527
相關(guān)產(chǎn)品	Fisetin \| Nicotinamide riboside \| Nicotinamide \| Resveratrol \| Dihydrocoumarin \| Sirtinol \| JGB1741 \| SRT 2104 \| Nicotinamide riboside chloride \| 3-TYP \| SIRT6-IN-5 \| MC3482
相關(guān)庫	經(jīng)典已知活性庫 \| 高選擇性抑制劑庫 \| 抗衰老化合物庫 \| 神經(jīng)退行性疾病化合物庫 \| 藥物功能重定位化合物庫 \| 抗癌藥物庫

關(guān)鍵字：司來司他|||SEN0014196|||EX-527|TargetMol

公司簡介

上海陶術(shù)生物科技有限公司為美國Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國波士頓、德國慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學(xué)研究的科學(xué)家提供優(yōu)質(zhì)的產(chǎn)品和專業(yè)的服務(wù)。公司下設(shè)篩選事業(yè)部，化學(xué)事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實(shí)體化合物分子供應(yīng)；從商業(yè)化產(chǎn)品銷售到個(gè)性化定制合成；從對(duì)明確靶點(diǎn)的分子篩選到對(duì)明確分子的多靶點(diǎn)篩選，從高通量篩選到化學(xué)結(jié)構(gòu)優(yōu)化，我們都可以滿足您的科研用品及技術(shù)服務(wù)的需求。經(jīng)過在中國市場五年的精心耕耘，我們已成為篩選化合物領(lǐng)域優(yōu)秀的供應(yīng)商，為超過五百家學(xué)校和各類企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （12年）	注冊(cè)資本	566.2651萬人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營行業(yè)	化學(xué)試劑,生物活性小分子	經(jīng)營模式	貿(mào)易,試劑,定制,服務(wù)

TargetMol中國（陶術(shù)生物）

VIP 12年

公司成立：12年
注冊(cè)資本：566.2651萬人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營產(chǎn)品：小分子抑制劑，藥物篩選化合物庫，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場三路28號(hào)4樓

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