Human CD206 / MMR Protein, His Tag
分子別名（Synonym）
MMR,CD206,hMR,MRC1,CLEC13D,CLEC13DL,MRC1L1
表達區(qū)間及表達系統(tǒng)（Source）
Human CD206, His Tag (CD6-H52H9) is expressed from human 293 cells (HEK293). It contains AA Leu 19 - Ala 1389 (Accession # P22897-1).
Predicted N-terminus: Leu 19
蛋白結(jié)構(gòu)（Molecular Characterization）
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 158.6 kDa. The protein migrates as 150-190 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
內(nèi)毒素（Endotoxin）
Less than 1.0 EU per μg by the LAL method.
純度（Purity）
>90% as determined by SDS-PAGE.
>90% as determined by SEC-HPLC.
制劑（Formulation）
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景（Background）
Mrc1是一種保守的檢查點介導蛋白，它將復制應激信號轉(zhuǎn)導給下游效應激酶。Mrc1及其脊椎動物同源物Claspin充當復制應激檢查點信號傳導的介質(zhì)，從Mec1/Rad3/ATR傳感器激酶接收信號并將其傳遞給效應器Rad53/Cds1/Chk1激酶。mrc1檢查點活性的喪失導致羥基脲存在時晚期/休眠起源的異常激活。表達多配體內(nèi)吞受體甘露糖受體（CD206/MRC1）的腫瘤相關(guān)巨噬細胞（TAM）有助于腫瘤免疫抑制、血管生成、轉(zhuǎn)移和復發(fā)。
關(guān)鍵字： CD206;CD206蛋白;CD206重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group（股票代碼：301080）是成立于2010年的跨國生物科技公司，是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球，橫跨亞洲、北美洲、歐洲，在中國、美國、瑞士等12個城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務客戶超6000家，與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。