CD206產(chǎn)品信息
英文名稱:Macrophage mannose receptor 1
中文名稱:巨噬細(xì)胞甘露糖受體-1
靶點(diǎn)別稱:MMR,CD206,hMR,MRC1,CLEC13D,CLEC13DL,MRC1L1
物種:Human/Mouse
屬性:Protein
標(biāo)記:Biotin-labeled/Unconjugated
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
CD206分子背景
Mrc1是一種保守的檢查點(diǎn)介導(dǎo)蛋白,它將復(fù)制應(yīng)激信號轉(zhuǎn)導(dǎo)給下游效應(yīng)激酶。Mrc1及其脊椎動物同源物Claspin充當(dāng)復(fù)制應(yīng)激檢查點(diǎn)信號傳導(dǎo)的介質(zhì),從Mec1/Rad3/ATR傳感器激酶接收信號并將其傳遞給效應(yīng)器Rad53/Cds1/Chk1激酶。mrc1檢查點(diǎn)活性的喪失導(dǎo)致羥基脲存在時(shí)晚期/休眠起源的異常激活。表達(dá)多配體內(nèi)吞受體甘露糖受體(CD206/MRC1)的腫瘤相關(guān)巨噬細(xì)胞(TAM)有助于腫瘤免疫抑制、血管生成、轉(zhuǎn)移和復(fù)發(fā)。
關(guān)鍵字: CD206;CD206蛋白;MMR;MMR蛋白;百普賽斯;
百普賽斯集團(tuán)ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團(tuán)業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個(gè)城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計(jì)服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團(tuán)旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。