Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free (MALS verified)
分子別名（Synonym）
Integrin alpha V beta 6,ITGAV&ITGB6
表達區(qū)間及表達系統(tǒng)（Source）
Human ITGAV&ITGB6 Heterodimer Protein, His Tag&Tag Free (IT6-H52E1) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 992 (ITGAV) & Gly 22 - Asn 707 (ITGB6) (Accession # NP_002201.1 (ITGAV) & AAI21179.1 (ITGB6)).
Predicted N-terminus: Phe 31 (ITGAV) & Gly 22 (ITGB6)
蛋白結(jié)構(gòu)（Molecular Characterization）
Human ITGAV&ITGB6 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAV and ITGB6, has a calculated MW of 112.9 kDa (ITGAV) & 79.6 kDa (ITGB6). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB6 contains no tag but a basic tail at the C-terminus. The protein migrates as 85 kDa (ITGB6) and 140 kDa (ITGAV) when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
內(nèi)毒素（Endotoxin）
Less than 1.0 EU per μg by the LAL method.
純度（Purity）
>95% as determined by SDS-PAGE.
制劑（Formulation）
Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景（Background）
整合素αVβ6是β6與αV結(jié)合的異二聚體。整合素αVα6是纖維連接蛋白和細(xì)胞觸覺素的受體。它識別其配體中的序列R-G-D。整合素α-Vβ-6通過網(wǎng)格蛋白介導(dǎo)的內(nèi)吞作用內(nèi)化，促進癌細(xì)胞侵襲。此外，整合素α-Vβ-6作為柯薩奇病毒A9和柯薩奇病毒B1以及單純皰疹病毒-1/HHV-1的受體。此外，它結(jié)合TGF-β潛伏相關(guān)肽（LAP），并從大的潛伏復(fù)合物中激活TGF-β1或TGF-β3。這種激活需要與LTBP-1和纖連蛋白相互作用，并通過PAR-1增強。
關(guān)鍵字： Integrin αVβ6;Integrin αVβ6蛋白;avb6重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group（股票代碼：301080）是成立于2010年的跨國生物科技公司，是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務(wù)遍布全球，橫跨亞洲、北美洲、歐洲，在中國、美國、瑞士等12個城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務(wù)客戶超6000家，與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。