Integrin alpha V beta 6產(chǎn)品信息
英文名稱:Integrin alpha-V/beta-6
中文名稱:整合素α-V/β-6復(fù)合體
靶點(diǎn)別稱:Integrin alpha V beta 6,ITGAV&ITGB6
物種:Human / Mouse / Cynomolgus / Rat
屬性:Protein / Cell
標(biāo)記:Biotin-labeled / Unconjugated
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(chǔ)(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
1. -20°C to -70°C for 12 months in lyophilized state;
2. -70°C for 3 months under sterile conditions after reconstitution.
Integrin alpha V beta 6分子背景
整合素αVβ6是β6與αV結(jié)合的異二聚體。整合素αVα6是纖維連接蛋白和細(xì)胞觸覺素的受體。它識(shí)別其配體中的序列R-G-D。整合素α-Vβ-6通過(guò)網(wǎng)格蛋白介導(dǎo)的內(nèi)吞作用內(nèi)化,促進(jìn)癌細(xì)胞侵襲。此外,整合素α-Vβ-6作為柯薩奇病毒A9和柯薩奇病毒B1以及單純皰疹病毒-1/HHV-1的受體。此外,它結(jié)合TGF-β潛伏相關(guān)肽(LAP),并從大的潛伏復(fù)合物中激活TGF-β1或TGF-β3。這種激活需要與LTBP-1和纖連蛋白相互作用,并通過(guò)PAR-1增強(qiáng)。
Integrin alpha V beta 6用戶評(píng)價(jià)
關(guān)鍵字: 整合素αvβ6;αvβ6整合素;integrin αvβ6;αvβ6;Integrin alpha V bet;
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