2-氯-5-氟苯酚中文同義詞2-氯-5-氟苯酚,98%;2-氯-5-氟苯酚;2-氯-5-氟苯酚(CAS號(hào):3827-49-4)英文名稱2-Chloro-5-fluorophenol英文同義詞2-CHLORO-5-FLUOROPHENOL;2-Chloro-5-fluorophenol,min.97%;2-Chloro-5-fluorophenol98%;2-Chloro-5-fluorophenol98%;2-Chloro-5-flurophenol;2-Chloro-5-fluorophenol,min.97%;Phenol,2-chloro-5-fluoro-;2-Chloro-5-fluorophenolISO9001：2015REACHCAS號(hào)3827-49-4分子式C6H4ClFO分子量146.55EINECS號(hào)609-539-1相關(guān)類別醫(yī)藥中間體;鹵代物;苯類;Alcohols;Aryl;ArylFluorinatedBuildingBlocks;BuildingBlocks;C2toC6;C6;ChemicalSynthesis;FluorinatedBuildingBlocks;Phenol&Thiophenol&Mercaptan;ChlorineCompounds;FluorineCompounds;Phenols;organofluorinecompounds;HalogenatedHydrocarbons;NewProductsforChemicalSynthesis;OrganicBuildingBlocks;OrganicFluorinatedBuildingBlocks;OtherFluorinatedOrganicBuildingBlocks;OxygenCompounds;FluorineseriesMol文件3827-49-4.mol結(jié)構(gòu)式2-氯-5-氟苯酚性質(zhì)沸點(diǎn)183-185°C密度1.3675(estimate)折射率1.524-1.526閃點(diǎn)183-185°C儲(chǔ)存條件Sealedindry,RoomTemperature酸度系數(shù)(pKa)7.50±0.10(Predicted)形態(tài)液體顏色透明無色至淡黃色水溶解性slightlysolubleCAS數(shù)據(jù)庫(kù)3827-49-4(CASDataBaseReference)2-氯-5-氟苯酚用途與合成方法簡(jiǎn)介2-氯-5-氟苯酚為透明無色至淡黃色液體，密度：1.408g/cm3，沸點(diǎn)：183-185°C。含氟類化合物是精細(xì)化工領(lǐng)域增長(zhǎng)最為迅速的化學(xué)品之一，特別是芳香族含氟化合物其合成方法的開發(fā)和應(yīng)用深受國(guó)內(nèi)外工業(yè)界、科學(xué)界的廣泛關(guān)注。用途2-氯-5-氟苯酚是一種藥物中間體，可用于合成一種三唑類的后葉催產(chǎn)素抗拈劑。合成方法有關(guān)2氯-5-氟苯酚的合成方法目前未見公開報(bào)道。本文采用對(duì)氟苯胺為原料，經(jīng)溴化、重氮化氯代和格氏反應(yīng)引入羥基，合成出2-氯-5-氟苯酚。其合成路線如下所示。圖12-氯-5-氟苯酚合成路線圖