Fc gamma RIIB / CD32b產(chǎn)品信息
英文名稱:Low affinity immunoglobulin gamma Fc region receptor II-b
中文名稱:低親和力免疫球蛋白γFc區(qū)受體II-B
靶點(diǎn)別稱:FCGR,Fc gamma RIIB / CD32b
物種:Human / Mouse / Cynomolgus / Rat
屬性:Protein / Cell
標(biāo)記:Biotin-labeled / Unconjugated
純度(Purity)
>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(chǔ)(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
1. -20°C to -70°C for 12 months in lyophilized state;
2. -70°C for 3 months under sterile conditions after reconstitution.
Fc gamma RIIB / CD32b分子背景
IgG Fc區(qū)受體(FcγR)是Ig超家族的成員,在激活或抑制免疫反應(yīng)中發(fā)揮作用。識(shí)別出三類人FcγRs:RI(CD64)、RII(CD32)和RIII(CD16),它們產(chǎn)生多種亞型。人類FcγRII/CD32有三個(gè)基因(A、B和C),小鼠FcγRII B有一個(gè)基因(CD32B)。CD32是IgG的低親和力受體。低親和力免疫球蛋白γFc區(qū)受體II-b(FCGR2B)也稱為CD32b、FCG2、IGFR2。CD32B在B細(xì)胞和髓樣樹(shù)突狀細(xì)胞上表達(dá)。B細(xì)胞上CD32B的連接下調(diào)了抗體的產(chǎn)生,在某些情況下可能會(huì)促進(jìn)細(xì)胞凋亡。樹(shù)突狀細(xì)胞上CD32B的共連接抑制成熟并阻斷細(xì)胞活化。CD32B也可能是惡性腫瘤單克隆抗體治療的靶點(diǎn)。
Fc gamma RIIB / CD32b用戶評(píng)價(jià)
關(guān)鍵字: Fc gamma RIIB/CD32b;Fc gamma RIIB;CD32b;CD32b蛋白;Fc gamma RIIB蛋白;
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