IL-23R產(chǎn)品信息
英文名稱:Interleukin 23 Receptor
中文名稱:白細(xì)胞介素23受體
靶點(diǎn)別稱:IL-23 R,IL-23 Receptor
物種:Human / Mouse / Cynomolgus
屬性:Protein
標(biāo)記:Biotin-labeled / Unconjugated
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>95% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(chǔ)(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
1. -20°C to -70°C for 12 months in lyophilized state;
2. -70°C for 3 months under sterile conditions after reconstitution.
IL-23R分子背景
白細(xì)胞介素23受體(IL-23R)是一種I型細(xì)胞因子受體,IL-23R與受體分子IL12RB1/IL12Rbeta1配對(duì),兩者都是IL23A信號(hào)傳導(dǎo)所必需的。此外,IL-23R與Janus激酶2(JAK2)組成型結(jié)合,并以配體依賴的方式與轉(zhuǎn)錄激活因子STAT3結(jié)合。此外,IL-23R可能通過(guò)激活Jak-Stat信號(hào)級(jí)聯(lián)來(lái)介導(dǎo)T細(xì)胞、NK細(xì)胞和某些巨噬細(xì)胞/髓系細(xì)胞的刺激。至于IL-23,它可能與自身免疫性炎癥性疾病有關(guān),對(duì)腫瘤發(fā)生很重要。
IL-23R用戶評(píng)價(jià)
關(guān)鍵字: IL-23R;白介素23R;白介素23受體;Interleukin 23R;IL-23 Receptor;
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