VH298

CAS號2097381-85-4

同義詞：VH-298游離態(tài);化合物VH-298;(2S,4R)-1-((S)-2-(1-氰基環(huán)丙基-1-甲酰胺基)-3,3-二甲基丁酰基)-4-羥基-N-(4-(4-甲基噻唑-5-基)芐基)吡咯烷-2-甲酰胺;(2S,4R)-1-((S)-2-(1-氰基環(huán)丙烷甲酰胺基)-3,3-二甲基丁?；?-4-羥基-N-(4-(4-甲基噻唑-5-基)芐基)吡咯烷-2-羧酰胺

分子式C27H33N5O4S

分子量523.65

VH-298 是一種高效的 VHL:HIF-α 相互作用抑制劑(Kd:80-90 nM)。它可用于PROTAC 技術(shù)中。

VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein-protein interaction downstream of HIF-α hydroxylation by PHD enzymes

存儲：

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