中文名：Etravirine (TMC125)
英文名：Etravirine (TMC125)
英文別名：R-165335;Benzonitrile, 4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethyl-
純度：10mM in DMSO
貨號：E408338
包裝：1ml
Cas號：269055-15-4
存儲溫度：-80℃儲存
產(chǎn)品介紹：
Information
Etravirine (TMC125) Etravirine (TMC125, R-165335) is a non-nucleoside reverse transcriptase inhibitor ( NNRTI ) used for the treatment of HIV.
In?vitro
Etravirine (TMC125), is highly active against wild-type HIV-1 with EC50 of 1.4 nM to 4.8 nM and shows some activity against HIV-2 with EC50 of 3.5 μM. TMC125 also inhibits a series of HIV-1 group M subtypes and circulating recombinant forms and a group O virus.
In?vivo
Etravirine has a high genetic barrier to the development of resistance. In phase IIb trials in treatment-experienced patients, including those infected with virus resistant to NNRTIs and protease inhibitors (PIs), TMC125 is active against HIV resistant to currently available NNRTIs, with a similar tolerability profile to that of the control group.
Cell?Data
cell?lines：
Concentrations：
Incubation?Time：
Powder?Purity:≥95%
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關(guān)鍵字： R-165335;Benzonitrile, 4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethyl-
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