中文名:磷霉素鈉鹽
英文名:Fosmidomycin sodium salt
中文別名:膦胺霉素鈉鹽
英文別名:Fosmidomycin Sodium Salt|Fosmidomycin Sodium|66508-37-0|(3-(Formylhydroxyamino)propyl)phosphonic acid monosodium salt|IYI1EW66CX|Phosphonic acid, (3-(formylhydroxyamino)propyl)-, monosodium salt|66508-37-0 (sodium)|FR-31564|Antibiotic FR 31564|UNII-IYI1EW
純度:>95.0%
貨號(hào):F302004
包裝:1mg、25mg、5mg
Cas號(hào):66508-37-0
存儲(chǔ)溫度:-20°C儲(chǔ)存,充氬
產(chǎn)品介紹:
Fosmidomycin sodium salt is a phosphonic acid antibiotic and a antimalarial drug, which is active against both Gram-negative and Gram-positive bacteria.
Fosmidomycin is a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXP). Fosmidomycin is an antibiotic originally isolated from bacteria of the genus Streptomyces.
1-deoxy-d-xylulose 5-phosphate reductoisomerase is an enzyme that interconverts DXP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
Fosmidomycin was active against both Gram-negative and Gram-positive bacteria and the human malarial parasite P. falciparum with the IC50 of 290-370 nM. Fosmidomycin inhibited 1-deoxy-d-xylulose 5-phosphate reductoisomerase in an alternative nonmevalonate pathway for terpenoid biosynthesis with IC50 of 8.2 nM. Fosmidomycin has been shown to possess activity against Plasmodium falciparum in vitro and in the mouse model. In patients with acute uncomplicated Plasmodium falciparum malaria, oral administration of 1,200 mg fosmidomycin every 8 h for 7 days was effective in curing uncomplicated Plasmodiumfalciparum malaria in humans. Fosmidomycin was an effective and safe antimalarial drug. The treatment was well tolerated and showed a fast parasite and fever clearance.
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關(guān)鍵字: 膦胺霉素鈉鹽;Fosmidomycin Sodium Salt;Fosmidomycin Sodium;66508-37-0
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