中文名：特立氟胺
英文名：Teriflunomide
中文別名：特立氟胺
英文別名：J-010046|MFCD00910058|HY-110159|NCGC00263218-07|A771726|A-771726|A77-1726|A801897|SW219377-1|2-Butenamide, 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-|2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide|Aubagio|HMS3886K11|AC-521|IRINOTECAN H
純度：≥99%
貨號：T124990
包裝：250mg、50mg
Cas號：163451-81-8
存儲溫度：2-8°C儲存
產(chǎn)品介紹：
A77 1726, also known as teriflunomide, is the active metabolite of leflunomide. This compound has demonstrated antiinflammatory, antiproliferative, and immunosuppressive effects. A77 1726 has been shown to inhibit the proliferation of multiple mammalian cell lines in vitro, has demonstrated inhibition of Cox-2, dendritic cell function, DHODH (dihydroorotate dehydrogenase), and blocks TNF-dependent nuclear factor-κ B activation and gene expression. DHODH is an enzyme involved in the de novo synthesis of pyrimidine nucleotides, and its inhibition is thoμght to result in the antiproliferative effects on rapidly dividing cells, such as T-cells, observed by this compound.
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關(guān)鍵字： 特立氟胺;J-010046;MFCD00910058;HY-110159
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