Mouse Anti-GRP78 Monoclonal Antibody
DATASHEET
Host:Mouse
Target Protein:GRP78
IR:Immunogen Range:
Clonality:Monoclonal
Isotype:IgG1,k
Entrez Gene:3309
Swiss Prot:P11021
Source:Recombinant human HSPA5 between 420-654 amino acids.:
Purification:affinity purified by Protein G
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The 78 kDa glucose regulated protein/BiP (GRP78) belongs to the family of ~70 kDa heat shock proteins (HSP 70). GRP78 is a resident protein of the endoplasmic reticulum (ER) and may associate transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins that are incorrectly folded, thus preventing their export from the ER lumen. GRP78 is a highly conserved protein that is essential for cell viability. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP 94) and protein disulfide isomerase (PDI). The presence of carboxy terminal KDEL appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
Cross Reactive Species:Human
Mouse
Rat
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關(guān)鍵字： GRP78;BIP;HSPA5;GRP-78;glucose regulated pr;78kDa;HSPA-5;GRP78_HUMAN;
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