Mouse Anti-GRP78/Bip Monoclonal Antibody
DATASHEET
Host:Mouse
Target Protein:GRP78/Bip
IR:Immunogen Range:
Clonality:Monoclonal
Isotype:IgG
Entrez Gene:3309
Swiss Prot:P11021
Source:KLH conjugated synthetic peptide derived from human GRP78/Bip:
Purification:affinity purified by Protein G
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The 78 kDa glucose regulated protein/BiP (GRP78) belongs to the family of ~70 kDa heat shock proteins (HSP 70). GRP78 is a resident protein of the endoplasmic reticulum (ER) and may associate transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins that are incorrectly folded, thus preventing their export from the ER lumen. GRP78 is a highly conserved protein that is essential for cell viability. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP 94) and protein disulfide isomerase (PDI). The presence of carboxy terminal KDEL appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-1000)
ICC(1:100)
Cross Reactive Species:Human
Rat
僅供科研使用。不能用于人和動(dòng)物治療等其它臨床診斷用！
關(guān)鍵字： GRP78/Bip;BIP;HSPA5;GRP-78;glucose regulated pr;78 kDa glucose regul;FLJ26106;GRP78_HUMAN;
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