Rabbit Anti-phospho-FLNC (Ser2233) Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:phospho-FLNC (Ser2233)
IR:Immunogen Range:LG(p-S)FG
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:2318
Swiss Prot:Q14315
Source:KLH conjugated synthesised phosphopeptide derived from human FLNC around the phosphorylation site of Ser2233:LG(p-S)FG
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Filamins are Actin-binding proteins which contain an N-terminal Actin-binding domain, a membrane glycoprotein domain and a C-terminal self-association domain. Filamins help reshape the cytoskeleton by forming flexible cross-links between two Actin filaments, which maintain membrane integrity during force application. Filamins also participate in signal transduction pathways associated with cell motility, adhesion, differentiation and survival, and force transduction. The filamin family is comprised of Filamin 1, Filamin 2 and Filamin 3. Filamin 2, also designated Filamin C, is a skeletal- and cardiac-muscle specific form of Filamin, which binds ?-sarcoglycan and ?-sarcoglycan, but not ?-sarcoglycan or ∫-sarcoglycan. Muscular dystrophy, an inherited group of disorders resulting in progressive weakness of muscles in the body, is associated with irregular subcellular localization of Filamin 2 caused by a deficiency in KY, a protein that interacts with Filamin 2.
Size:50ul
Concentration:1mg/ml
Applications:IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
Horse
Sheep
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關(guān)鍵字： phospho-FLNC (Ser223;FLNC (phospho S2233);p-Filamin 2 (phospho;ABPL;ABP 280;FLJ10186;Filamin-C;FLNC_HUMAN;
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