Product Name：Nerofe
CAS No.：2120397-85-3
Synonyms：Tcapf；腫瘤細(xì)胞凋亡因子激素肽
Catalog No.：218P422
Brand：HongTide（上海鴻肽生物）
Description：Nerofe是一種合成的14個氨基酸的肽，多肽序列中含有13個D型的氨基酸，來源于一種新型的人類肽類激素——腫瘤細(xì)胞細(xì)胞凋亡因子（TCApF），具有潛在的抗腫瘤活性。作為藥物使用時，靜脈給藥后，Nerofe與T1/ST2受體（IL1RL1）結(jié)合，并激活caspase 8和Bcl-2介導(dǎo)的細(xì)胞凋亡，此外還激活腫瘤細(xì)胞中p38 MAPK和JNK信號級聯(lián)。此外，該制劑通過抑制血管內(nèi)皮生長因子A（VEGFA）和fms相關(guān)酪氨酸激酶1（VEGFR1）的表達(dá)來抑制血管生成。Nerofe也通過增加白介素-10和抗血管生成白介素的表達(dá)來調(diào)節(jié)免疫系統(tǒng)反應(yīng)。T1/ST2受體是toll/白細(xì)胞介素-1受體超家族的成員，在某些癌癥細(xì)胞中過表達(dá)。本公司生產(chǎn)的Nerofe屬于研發(fā)級多肽。
Nerofe is a synthetic peptide with 14 amino acids. The peptide sequence contains 13 D-type amino acids. It is derived from a new human Peptide hormone, tumor cell apoptosis factor (TCApF), and has potential anti-tumor activity. When used as a drug, after intravenous administration, Nerofe binds to the T1/ST2 receptor (IL1RL1) and activates caspase 8 and Bcl-2 mediated cell apoptosis. In addition, it also activates the p38 MAPK and JNK signaling cascade in tumor cells. In addition, the preparation inhibits angiogenesis by inhibiting the expression of Vascular endothelial growth factor A (VEGFA) and fms related Tyrosine kinase 1 (VEGFR1). Nerofe also regulates the immune system response by increasing the expression of interleukin-10 and anti angiogenic interleukin. T1/ST2 receptors are members of the toll/interleukin-1 receptor superfamily and are overexpressed in certain cancer cells. The Nerofe produced by our company belongs to the research and development level peptide.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | d（WWTFFLPSTLWERK） |
Sequence(3-letter code) | H-D-Trp-D-Trp-D-Thr-D-Phe-D-Phe-D-Leu-D-Pro-D-Ser-D-Thr-D-Leu-D-Trp-D-Glu-D-Arg-D-Lys-OH |
Peptide Structure | 
|
Molecular Formula | C96H129N21O20 |
Molecular Weight | 1897.2 |
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關(guān)鍵字： 2120397-85-3;Nerofe ;腫瘤細(xì)胞凋亡因子激素肽;多肽;多肽合成;
上海鴻肽生物科技有限公司（簡稱：鴻肽生物）是一家以多肽以及多肽上下游產(chǎn)品研發(fā)、生產(chǎn)、銷售以及技術(shù)轉(zhuǎn)讓為主要業(yè) 務(wù)科技公司。公司現(xiàn)有產(chǎn)品涵蓋：定制多肽、目錄多肽、氨基酸衍生物、小分子化合物；公司自成立以來，秉持“用質(zhì)量作船， 以服務(wù)為帆，為科研服務(wù)”的企業(yè)理念，為國內(nèi)外眾多科研工作者提供了優(yōu)質(zhì)的服務(wù)及產(chǎn)品。