Rabbit Anti-Vitronectin Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:Vitronectin
IR:Immunogen Range:381-478/478
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:7448
Swiss Prot:P04004
Source:KLH conjugated synthetic peptide derived from human Vitronectin:381-478/478
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Vitronectin (also known as serum spreading factor, S protein of complement or epibolin) is one of the major multifunctional cell adhesive glycoproteins in mammalian plasma and serum. It is a monomeric acidic glycoprotein detected as a mixture of 75 kD and 65 kD polypeptides. Vitronectin binds to heparin, collagen, streptococci and variety of cultured cells. It also acts as an inhibitor of the complement cascade by binding to the C5b9 complex. Vitronectin promotes cell adhesion and spreading by binding through its cell attachment tripeptide Arg-Gly-Asp (RG-D), activity which is mediated by several different integrin receptors. Apart from the significance for identifying the molecule in the above situations, it also plays an important role in events such as embryonal development, deposition of vitronectin in a number of fibrotic disease states, carcinomas and metastases.
Size:50ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Cow
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關(guān)鍵字： Vitronectin;Complement S Protei;Epibolin;S Protein;Serum Spreading Fact;V75;Vitronectin V10 subu;VTNC_HUMAN;
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