Product Name：Jingzhaotoxin III
CAS No.：925463-91-8
Synonyms：NaV1.5通道阻斷劑多肽
Catalog No.：218P177
Brand：HongTide（上海鴻肽生物）
Description：Jingzhaotoxin III 是 NaV1.5 通道的選擇性阻斷劑 (IC50=348 nM)多肽，是由36個氨基酸組成的環(huán)狀多肽，多肽結(jié)構(gòu)中含有三對二硫鍵，對其他亞型沒有影響，包括 NaV1.2、NaV1.4、NaV1.6 和 NaV1.7。 認(rèn)為通過與域 II 的 NaV1.5 S3-S4 接頭結(jié)合來抑制鈉通道激活。Jingzhaotoxin III可選擇性抑制心臟鈉通道的激活，但對背根神經(jīng)節(jié)神經(jīng)元的鈉通道沒有影響。
Jingzhaotoxin III is a selective blocker (IC50=348 nM) peptide of the NaV1.5 channel. It is a cyclic peptide composed of 36 amino acids and contains three pairs of disulfide bonds, which have no effect on other subtypes, including NaV1.2, NaV1.4, NaV1.6, and NaV1.7. It is believed that the activation of sodium channels can be inhibited by binding to the NaV1.5 S3-S4 junction of domain II. Jingzhaotoxin III can selectively inhibit the activation of cardiac sodium channels, but has no effect on the sodium channels of dorsal root ganglion neurons.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | DGECGGFWWKCGRGKPPCCKGYACSKTWGWCAVEAP(Disulfide bridge：Cys4-Cys19;Cys11-Cys24;Cys18-Cys31) |
Sequence(3-letter code) | H-Asp-Gly-Glu-Cys-Gly-Gly-Phe-Trp-Trp-Lys-Cys-Gly-Arg-Gly-Lys-Pro-Pro-Cys-Cys-Lys-Gly-Tyr-Ala-Cys-Ser-Lys-Thr-Trp-Gly-Trp-Cys-Ala-Val-Glu-Ala-Pro-OH(Disulfide bridge：Cys4-Cys19;Cys11-Cys24;Cys18-Cys31) |
Peptide Structure | 
|
Molecular Formula | C174H241N47O46S6 |
Molecular Weight | 3919.48 |
訂購聯(lián)系方式：
上海鴻肽生物科技有限公司
手機： +86-18018095145 （同微信號）
QQ: 3259098395
郵箱：sales1@hongtide.com
關(guān)鍵字： 925463-91-8;NaV1.5通道阻斷劑多肽;Jingzhaotoxin III;多肽;多肽合成;
上海鴻肽生物科技有限公司（簡稱：鴻肽生物）是一家以多肽以及多肽上下游產(chǎn)品研發(fā)、生產(chǎn)、銷售以及技術(shù)轉(zhuǎn)讓為主要業(yè) 務(wù)科技公司。公司現(xiàn)有產(chǎn)品涵蓋：定制多肽、目錄多肽、氨基酸衍生物、小分子化合物；公司自成立以來，秉持“用質(zhì)量作船， 以服務(wù)為帆，為科研服務(wù)”的企業(yè)理念，為國內(nèi)外眾多科研工作者提供了優(yōu)質(zhì)的服務(wù)及產(chǎn)品。