Product Name：Guangxitoxin 1E
CAS No.：1233152-82-3
Synonyms：通道阻滯劑多肽Guangxitoxin 1E
Catalog No.：218P140
Brand：HongTide（上海鴻肽生物）
Description：Guangxitoxin 1E是一種Kv2.1和Kv2.2通道阻滯劑多肽，是由36個氨基酸組成的環(huán)狀多肽，序列中含有三對二硫鍵，IC50值為1-3nM。Guangxitoxin 1E在體外增強(qiáng)人胰島的葡萄糖刺激胰島素分泌，但不增強(qiáng)缺乏 Kv2.1通道的胰島細(xì)胞的胰島素分泌。Guangxitoxin 1E對小鼠的血漿胰島素、胰高血糖素或血糖水平?jīng)]有顯著影響，但會增加血漿生長抑素水平。
Guangxitoxin 1E is a Kv2.1 and Kv2.2 channel blocker peptide composed of 36 amino acids, with three pairs of disulfide bonds in its sequence and an IC50 value of 1-3nM. Guangxitoxin 1E enhances glucose stimulated insulin secretion in human pancreatic islets in vitro, but does not enhance insulin secretion in pancreatic islet cells lacking Kv2.1 channels. Guangxitoxin 1E has no significant effect on the plasma insulin, glucagon or blood sugar levels of mice, but will increase the plasma somatostatin level.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | EGECGGFWWKCGSGKPACCPKYVCSPKWGLCNFPMP(Disulfide bridges: 4-19,11-24,18-31) |
Sequence(3-letter code) | H-Glu-Gly-Glu-Cys-Gly-Gly-Phe-Trp-Trp-Lys-Cys-Gly-Ser-Gly-Lys-Pro-Ala-Cys-Cys-Pro-Lys-Tyr-Val-Cys-Ser-Pro-Lys-Trp-Gly-Leu-Cys-Asn-Phe-Pro-Met-Pro-OH(Disulfide bridge：Cys4-Cys19;Cys11-Cys24;Cys18-Cys31) |
Peptide Structure | 
|
Molecular Formula | C178H248N44O45S7 |
Molecular Weight | 3948.61 |
訂購聯(lián)系方式：
上海鴻肽生物科技有限公司
手機(jī)： +86-18018095145 （同微信號）
QQ: 3259098395
郵箱：sales1@hongtide.com
關(guān)鍵字： 1233152-82-3;Guangxitoxin 1E;通道阻滯劑多肽;多肽;多肽合成;
上海鴻肽生物科技有限公司（簡稱：鴻肽生物）是一家以多肽以及多肽上下游產(chǎn)品研發(fā)、生產(chǎn)、銷售以及技術(shù)轉(zhuǎn)讓為主要業(yè) 務(wù)科技公司。公司現(xiàn)有產(chǎn)品涵蓋：定制多肽、目錄多肽、氨基酸衍生物、小分子化合物；公司自成立以來，秉持“用質(zhì)量作船， 以服務(wù)為帆，為科研服務(wù)”的企業(yè)理念，為國內(nèi)外眾多科研工作者提供了優(yōu)質(zhì)的服務(wù)及產(chǎn)品。