Product Name：Hepcidin-25
CAS No.：1356390-47-0
Synonyms：Hepcidin-25 (human) trifluoroacetate salt；LEAP-1；肝殺菌蛋白；鐵調(diào)素
Catalog No.：159P05
Brand：HongTide（上海鴻肽生物）
Description：Hepcidin-25也稱為LEAP-1（肝臟表達(dá)的抗菌肽）在人血液超濾液和尿液中獨(dú)立發(fā)現(xiàn)。該肽主要在肝臟中表達(dá)，屬于新的脊椎動物小抗菌肽家族，含有8個半胱氨酸殘基，顯示出顯著的抗菌和抗真菌活性。 進(jìn)一步的研究表明，hepicidin 是人類主要的鐵調(diào)節(jié)激素。 Hepcidin-25通過與鐵轉(zhuǎn)運(yùn)蛋白結(jié)合，誘導(dǎo)其內(nèi)化和降解，從而阻斷細(xì)胞鐵流出。
Hepcidin-25, also known as LEAP-1 (liver expressed antimicrobial peptide), is independently found in human blood ultrafiltration and urine. This peptide is mainly expressed in the liver and belongs to a new family of small antimicrobial peptides in vertebrates. It contains 8 cysteine residues and exhibits significant antibacterial and antifungal activities. Further research suggests that hepicidin is the main iron regulatory hormone in humans.Hepcidin-25 induces internalization and degradation by binding to iron transporters, thereby blocking cellular iron efflux.
Purity (HPLC) ≥75.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | DTHFPICIFCCGCCHRSKCGMCCKT(Disulfide bonds between Cys7 and Cys23；Cys10 and Cys13；Cys11 and Cys19；Cys14 and Cys22) |
Sequence(3-letter code) | H-Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr-OH(Disulfide bonds between Cys7 and Cys23；Cys10 and Cys13；Cys11 and Cys19；Cys14 and Cys22) |
Peptide Structure | 
|
Molecular Formula | C113H170N34O31S9 |
Molecular Weight | 2789.35 |
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關(guān)鍵字： Hepcidin-25;1356390-47-0;肝殺菌蛋白;鐵調(diào)素;Hepcidin-25 (human) ;
上海鴻肽生物科技有限公司（簡稱：鴻肽生物）是一家以多肽以及多肽上下游產(chǎn)品研發(fā)、生產(chǎn)、銷售以及技術(shù)轉(zhuǎn)讓為主要業(yè) 務(wù)科技公司。公司現(xiàn)有產(chǎn)品涵蓋：定制多肽、目錄多肽、氨基酸衍生物、小分子化合物；公司自成立以來，秉持“用質(zhì)量作船， 以服務(wù)為帆，為科研服務(wù)”的企業(yè)理念，為國內(nèi)外眾多科研工作者提供了優(yōu)質(zhì)的服務(wù)及產(chǎn)品。