產(chǎn)品屬性:
產(chǎn)品名稱 | 規(guī)格 | CAS號(hào) | 型號(hào) |
Ganodermanontriol | 1 mg 5 mg | 106518-63-2 | EY-Y0164937 |
Cas No.106518-63-2
別名 N/A
化學(xué)名 N/A
分子式 C30H48O4
分子量 472.7
溶解度 Chloroform: soluble
儲(chǔ)存條件 Store at-20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述:
Ganodermanontriol is a triterpene that has been found in G. lucidum and has diverse biological activities.1,2,3,4 It inhibits the activity of HIV-1 protease (IC50 = 70 μM), as well as reduces the activity of 5α-reductase by 32% when used at a concentration of 667 μM.1,2 Ganodermanontriol (25 and 50 μM) inhibits proliferation, colony formation, invasion, and migration of MDA-MB-231 human breast cancer cells.3 It reduces hepatocyte necrosis and increases in hepatic TNF-α and IL-6 levels in a mouse model of LPS/D-galactosamine-induced acute liver injury when administered at a dose of 5 mg/kg.4
1.Min, B.-S., Nakamura, N., Miyashiro, H., et al.Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 proteaseChem. Pharm. Bull.46(10)1607-1612(1998) 2.Liu, J., Kurashiki, K., Shimizu, K., et al.Structure-activity relationship for inhibition of 5α-reductase by triterpenoids isolated from Ganoderma lucidumBioorg. Med. Chem.14(24)8654-8660(2006) 3.Jiang, J., Jedinak, A., and Silva, D.Ganodermanontriol (GDNT) exerts its effect on growth and invasiveness of breast cancer cells through the down-regulation of CDC20 and uPABiochem. Biophys. Res. Commun.415(2)325-329(2011) 4.Hu, Z., Du, R., Xiu, L., et al.Protective effect of triterpenes of Ganoderma lucidum on lipopolysaccharide-induced inflammatory responses and acute liver injuryCytokine127154917(2020)
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關(guān)鍵字: 106518-63-2;C30H48O4;Ganodermanontriol;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要從事免疫學(xué)、分子生物學(xué)和常規(guī)生化試劑等為一體的科研產(chǎn)品銷售企業(yè),公司自成立以來(lái),秉承""全心全意服務(wù)于科研工作者""的企業(yè)理念,立足生物科技領(lǐng)域,運(yùn)用生物技術(shù)和科研試劑,發(fā)展現(xiàn)代生物科技,為各類大中小醫(yī)院及其它醫(yī)療機(jī)構(gòu)、高等院校、科研院所、企事業(yè)單位提供優(yōu)質(zhì)的產(chǎn)品,服務(wù)生物科技領(lǐng)域的科學(xué)研究人員。
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