Name: BRF110
CAS#: 2095489-35-1
Chemical Formula: C22H18F3N3O2
Exact Mass: 413.1351
Molecular Weight: 413.4002
Elemental Analysis: C, 63.92; H, 4.39; F, 13.79; N, 10.16; O, 7.74
Description: BRF110 is a brain penetrant, potent and selective agonist of nuclear receptor-related 1 (Nurr1):Retinoid X receptor α (RXRα) heterodimer. BRF110 is a neuroprotective agent that prevents dopaminergic neuron demise and striatal dopaminergic denervation in vivo against PD-causing toxins. It induced dopamine biosynthesis in vivo. BRF110 chronic dosing does not induce dyskinesia in mice model.
IUPAC/Chemical Name: 4-((5-allyl-2-phenyl-6-(trifluoromethyl)pyrimidin-4-yl)(methyl)amino)benzoic acid
InChi Key: WFLMIJKKTIOYSO-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H18F3N3O2/c1-3-7-17-18(22(23,24)25)26-19(14-8-5-4-6-9-14)27-20(17)28(2)16-12-10-15(11-13-16)21(29)30/h3-6,8-13H,1,7H2,2H3,(H,29,30)
SMILES Code: CN(C1=NC(C2=CC=CC=C2)=NC(C(F)(F)F)=C1CC=C)C3=CC=C(C(O)=O)C=C3
Appearance: Solid powder
關(guān)鍵字： 2095489-35-1;BRF110;BRF-110;
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