Name: BPKDi
CAS#: 1201673-28-0
Chemical Formula: C21H28N6O
Exact Mass: 380.2325
Molecular Weight: 380.49
Elemental Analysis: C, 66.29; H, 7.42; N, 22.09; O, 4.20
Description: BPKDi is an inhibitor of protein kinase D (PKD; IC50s = 1, 9, and 1 nM for PKD1, PKD2, and PKD3, respectively). It is selective for PKD over PKCδ and PKCε, as well as over a panel of additional calcium/calmodulin-dependent protein kinase (CaMK) superfamily members, at 1 μM. It inhibits phenylephrine-induced phosphorylation and nuclear export of histone deacetylase 4 (HDAC4) and HDAC5 in, as well reduces phenylephrine-induced hypertrophy of, isolated neonatal rat ventricular myocytes when used at a concentration of 1 μM.
IUPAC/Chemical Name: 2'-(Cyclohexylamino)-6-(1-piperazinyl)-[2,4'-bipyridine]-4-carboxamide
InChi Key: XNWDRALEEPGBHB-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H28N6O/c22-21(28)16-12-18(26-20(14-16)27-10-8-23-9-11-27)15-6-7-24-19(13-15)25-17-4-2-1-3-5-17/h6-7,12-14,17,23H,1-5,8-11H2,(H2,22,28)(H,24,25)
SMILES Code: O=C(C1=CC(C2=CC(NC3CCCCC3)=NC=C2)=NC(N4CCNCC4)=C1)N
Appearance: Solid powder
關(guān)鍵字： 1201673-28-0;BPKDi;BPKD i;
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