進(jìn)口原料鹽酸西替利嗪83881-52-1供應(yīng)
進(jìn)口原料鹽酸西替利嗪83881-52-1供應(yīng)
進(jìn)口原料鹽酸西替利嗪83881-52-1供應(yīng)
中文名稱:鹽酸西替利嗪中文同義詞:西替利嗪鹽酸鹽;鹽酸西替利嗪,一種選擇性組胺H1受體拮抗劑;鹽酸西替立嗪;(+/-)-2-[2-[4-[(4-氯苯基)苯甲基]-1-哌嗪基]乙氧基]乙酸二鹽酸鹽;鹽酸西替利嗪;鹽酸西替利嗪(標(biāo)準(zhǔn)品);鹽酸西替利嗪溶液,100PPM;鹽酸西替利嗪1KG英文名稱:Cetirizinehydrochloride英文同義詞:(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)aceticaciddihydro;2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]aceticaciddihydrochloride;CetirizineHydrochloride(250mg);Alercet;Alerid;Cesta;Cetiriz;CetrakCAS號(hào):83881-52-1分子式:C21H26Cl2N2O3分子量:425.35EINECS號(hào):620-533-8相關(guān)類別:藥物原料;中藥對(duì)照品;標(biāo)準(zhǔn)品;原料;醫(yī)藥原料;小分子抑制劑;中間體;細(xì)胞信號(hào)和神經(jīng)生物學(xué);Intermediates&FineChemicals;Pharmaceuticals;原料藥;細(xì)胞生物學(xué);API;Aromatics,Heterocycles,Metabolites&Impurities,Pharmaceuticals,Intermediates&FineChemicals;DOPRAM;心腦血管類科研原料藥;添加劑;原料;標(biāo)準(zhǔn)品-中藥標(biāo)準(zhǔn)品;化工中間體工業(yè)原料;醫(yī)藥原料藥;添加劑;有機(jī)化學(xué);日用化學(xué)品;ActivePharmaceuticalIngredients;Histaminereceptor;Aromatics;Heterocycles;Metabolites&ImpuritiesMol文件:83881-52-1.mol鹽酸西替利嗪性質(zhì)熔點(diǎn)110-115°C儲(chǔ)存條件2-8°C溶解度H2O:soluble5mg/mL,clear形態(tài)powder顏色whitetobeige水溶解性Solubleinwater,DMSO,ethanol,andmethanol.Merck14,2022InChIKeyPGLIUCLTXOYQMV-UHFFFAOYSA-NCAS數(shù)據(jù)庫83881-52-1(CASDataBaseReference)EPA化學(xué)物質(zhì)信息Aceticacid,2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-,hydrochloride(1:2)(83881-52-1)鹽酸西替利嗪用途與合成方法抗過敏藥鹽酸西替利嗪是安他樂的羥基衍生物,是一種抗過敏藥,是新一代H1受體拮抗劑,屬第二代H1抗組胺藥,無抗膽堿和抗5-羥色胺的作用,極少透過血腦屏障。對(duì)不同化學(xué)誘導(dǎo)性介質(zhì)包括血管活性多肽、P物質(zhì)及神經(jīng)肽等和嗜酸性粒細(xì)胞趨化反應(yīng)有抑制作用,口服見效快,作用強(qiáng)而持久。副作用輕微,表現(xiàn)為嗜睡、疲勞,表情淡漠、注意力不集中等,一般不必停藥。臨床上用于治療季節(jié)性或常年性過敏性鼻炎、由過敏原引起的蕁麻疹及皮膚瘙癢,用法用量:成人和12歲以上者每次10mg,兒童0.1~0.5mg/kg·d,每日1次。從2008年1月11日起,我國將鹽酸西替利嗪由處方藥轉(zhuǎn)換為非處方藥。在香港以治敏速的名字由葛蘭素史克以非處方藥發(fā)售。西替利嗪的有效成分旋西替利嗪是鹽酸西替利嗪的光學(xué)異構(gòu)體之一(左旋體)。ChemicalBookandy整理編輯。生物活性CetirizineDiHCl(UCBP071)是一種抗組胺劑。靶點(diǎn)TargetValueHistaminereceptor體外研究Cetirizine(>5μM)athigherconcentrationscanreducethereleaseofGM-CSFandIL-8fromA549cellsstimulatedwithIL-1β.Cetirizineexertsanti-inflammatoryeffectsbeyondhistamineH1-receptorantagonist[2].CellViabilityAssay[2]CellLine:HumanairwayepithelialcelllineA549.Concentration:0-10μM.IncubationTime:24h.Result:ThesurvivalofA549cellsincubatedwithvariousconcentrationsofcetirizine(0.1,1,2.5,5,and10μM)for24hourswereallhigherthan90%whencomparingwiththecontrolgroupbyMTTtest.Cetirizine,5and10μM,suppressedGM-CSFreleaseby70.71and61.55%,respectively.Preincubationwithcetirizine,10μM,suppressedtheIL-8secretionby75.04%.體內(nèi)研究Cetirizine(20mg/kg,mice,orally)exertsitsanti-inflammatoryeffectsbyinhibitingMIFaswellasIL-8productioninmiceimmunizedandchallengedwithragweedpollen[3].AnimalModel:Male8-week-oldBALB/cmice(25-30g)immunizedandchallengedwithragweedpollen[3].Dosage:2or20mg/kg.Administration:Orally,dilutedinsterilewaterondays18,19,and20.Result:Theneutrophiliaat8handeosinophiliaat24hinducedbyragweedpollenextractperosweresignificantlyreducedinthemicetreatedwith20mg/kg.Thedosagewith2mg/kghadnoeffect.用途主要用于呼吸系統(tǒng)、皮膚和眼睛的過敏性疾病
關(guān)鍵字: 鹽酸西替利嗪;進(jìn)口鹽酸西替利嗪;鹽酸西替利嗪原料;鹽酸西替利嗪供應(yīng);83881-52-1;
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