英文名稱:
RESIQUIMOD
CAS號(hào):
144875-48-9
分子式:
C17H22N4O2
分子量:
314.38
屬性
熔點(diǎn)
190-193°
沸點(diǎn)
553.6±50.0 °C(Predicted)
密度
1.28
儲(chǔ)存條件
?20°C
溶解度
DMSO: soluble10mg/mL, clear (warmed to 60 °C)
酸度系數(shù)(pKa)
14.63±0.29(Predicted)
形態(tài)
powder
顏色
white to tan
波長(zhǎng)(λmax)
325nm(lit.)
Merck
14,8151
InChIKey
BXNMTOQRYBFHNZ-UHFFFAOYSA-N
Resiquimod is a low-molecular-weight immune response modifier. It is reported to possess anti-tumor and anti-viral properties. It has been shown to mimic pathogen associated molecular patterns, activating immune cells through TLR7 and TLR8 (Toll-like receptors 7 and 8). It can induce interferon-alpha sythesis as well as the synthesis of other cytokines in various cell types. Evidence suggests its efficacy again herpes simples virus (HSV) type 2 in vivo. It has been shown to up-regulate IFN-γ production and proliferation by memory CD4+ T cells. It has also been shown to mimic CD40-induced B cell activation. R-848 is an activator of TLR7 and TLR8.
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