中文名稱 
2,5-二羥基苯甲酸.
中文別名 
2,5-二羥基苯甲酸;5-羥基水楊酸;龍膽酸;氫醌羧酸;2,5-二羥基苯甲酸(龍膽酸);2,5-二羥苯甲酸;龍膽酸;2,5-Dihydroxybenzoic Acid 2,5-二羥基苯甲酸;2.5-二羥基苯甲酸;美拉沙嗪雜質(zhì)G(EP) 標(biāo)準(zhǔn)品;美沙拉嗪雜質(zhì)G;2,5-二羥基苯甲酸 標(biāo)準(zhǔn)品;MS] 2,5-二羥基苯甲酸[ MALDI-TOF;MS基質(zhì)];龍膽酸,2,5-二羥基苯甲酸,5-羥基水楊酸;龍膽酸,5-羥基水楊酸;龍膽酸,氫醌羧酸;2,5-二羥基苯甲酸，醫(yī)藥級(jí),純度:>99%
英文名稱 
gentisate
英文別名 
2,5-Dihydroxybenzoic acid;Gentisic acid;Hydroquinonecarboxylic acid;2,5-Dhba;2,5-dihydroxy-benzoicaci;2,5-Dioxybenzoic acid;5-Hydroxysalicylic acid;5-hydroxy-salicylicaci;acido2,5-diidrossibenzoico;Benzoic acid, 2,5-dihydroxy-;2,5-Dihydroxybenzoic Acid (DHB);2.5-Dihydroxybenzoicacid;GENTISIC ACID(RG);2,5-DHBA,DHB,Gentisic acid;2,5-dihydroxybenzoate;2,5-dihydroxy-benzoic acid;2,5-dihydroxyphenylcarboxylic acid;Benzoic acid,2,5-dihydroxy;Gensigen;Gensigon;Gentisate;Hydroquinonecarboxylic acid;MS];DHB;DHBA;2,5-Dihydroxy benzoic acid;Gentisinic acid;Carboxyhydroquinone;Salicylic acid, 5-hydroxy-;Kyselina gentisinova;Gentisinate;Kyselina gentisinova [Czech];Acido gentisico [INN-Spanish];Kyselina 2,5-dihydroxybenzoova;Acidum gentisicum [INN-Latin];Acide gentisique [INN-French];Acido 2,5
Cas No. 
490-79-9
分子式 
C7H6O4
分子量 
154.12
包裝儲(chǔ)存 
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

生物活性 
2,5-Dihydroxybenzoic acid is a derivative of benzoic and a powerful inhibitor of fibroblast growth factors.
性狀 
Solid
IC50 & Target[1][2] 
Fibroblast growth factor
 
Human Endogenous Metabolite
 
體外研究(In Vitro) 
2,5-Dihydroxybenzoic acid (Gentisic acid) is a derivative of benzoic and a minor product of the metabolic break down of aspirin. 2,5-Dihydroxybenzoic acid is also a component of many traditional liquors and herbal remedies, is singled out as a powerful inhibitor of fibroblast growth factors. 2,5-Dihydroxybenzoic acid is used as a lead to identify additional compounds with better inhibitory characteristics generating a new chemical class of fibroblast growth factor inhibitors that includes the agent responsible for alkaptonuria. Through low and high resolution approaches, using representative members of the fibroblast growth factor family and their cell receptors, it is shown that this class of inhibitors may employ two different mechanisms to interfere with the assembly of the signaling complexes that trigger fibroblast growth factor-driven mitogenesis.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究(In Vivo) 
It is verified from in vivo disease models that this group of inhibitors (e.g., 2,5-Dihydroxybenzoic acid) may be of interest to treat cancer and angiogenesis-dependent diseases.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
運(yùn)輸條件 
Room temperature or refrigerated transportation.
儲(chǔ)存方式 
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
結(jié)構(gòu)分類 
Phenols
Polyphenols
Ketones, Aldehydes, Acids
參考文獻(xiàn) 
[1]. Levy G, et al. Salicylate accumulation kinetics in man. N Engl J Med. 1972 Aug 31;287(9):430-2.  [Information]
[2]. IS Fernández, et al. Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors. Journal of Biological Chemistry , 2010, 285(15):11714-29.  [Information]