| Identification | Back Directory | [Name]
Bepridil hydrochloride | [CAS]
74764-40-2 | [Synonyms]
angopril
Unii-4W2p15D93m
Bepridil hydrochloride
UEECHQPWQHYEDE-UHFFFAOYSA-N
Bepridil hydrochloride salt
Bepridil hydrochloride hydrate
Bepridil hydrochloride USP/EP/BP
l)-,monohydrochloride,monohydrate
1-Isobutoxy-2-pyrrolidino-3-(N-benzylanilino)propane hydrochloride
N-Benzyl-N-(3-isobutoxy-2-pyrrolidin-1-yl-propyl)anilinehydrochloride
3-isobutoxy-2-pyrrolidino-n-phenyl-n-benzylpropylaminehydrochloridehydrate
1-Pyrrolidineethanamine, β-[(2-methylpropoxy)methyl]-N-phenyl-N-(phenylmethyl)-, hydrochloride, hydrate (1:1:1)
1-Pyrrolideneethanamine, beta-((2-methylpropoxy)methyl)-N-phenyl-N-(phenylmethyl)-, monohydrochloride, monohydrate | [Molecular Formula]
C24H37ClN2O2 | [MDL Number]
MFCD00065498 | [MOL File]
74764-40-2.mol | [Molecular Weight]
421.016 |
| Chemical Properties | Back Directory | [Melting point ]
91 ±2° | [storage temp. ]
Desiccate at RT | [solubility ]
Soluble in DMSO (up to 25 mg/ml) or ethanol (up to 25 mg/ml) | [form ]
powder
| [color ]
white
| [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| Hazard Information | Back Directory | [Uses]
antineoplastic, alkylating agent | [Definition]
ChEBI: The hydrochloride monohydrate of bepridril. | [Brand name]
Bepadin
(Medpointe); Vascor (Johnson & Johnson). | [Hazard]
Moderately toxic by ingestion. | [Description]
Bepridil (74764-40-2) is a clinically useful calcium channel blocker with antianginal activity.1 It has recently been shown to possess potent activity against SARS-CoV-2 in vitro.2 Bepridil was also able to provide protection from Ebola virus3 and other filoviruses in a mouse model4. | [General Description]
Bepridil hydrochloride,β-[(2-methylpropoxy)methyl]-N-phenyl-N-(phenylmethyl)-1-pyrrolidineethylamine hydrochloride (Vascor), is a secondgenerationalkylamine-type channel blocker, structurallyunrelated to the dihydropyridines. Its actions are less specificthan those of the three prototypical channel blockers,verapamil, diltiazem, and nifedipine. In addition to being aCa2+ channel blocker, it inhibits sodium flow into the hearttissue and lengthens cardiac repolarization, causing bradycardia.Caution should be used if it is given to a patient withhypokalemia. Bepridil hydrochloride is used for stableangina. The drug has a half-life of 33 hours and is highlybound to protein (99%). | [Biochem/physiol Actions]
Non-selective calcium channel blocker and class IV antiarrhythmic agent; inhibits Na+-Ca2+ exchange; inhibits growth of brain tumor cells in vitro. | [Mechanism of action]
In addition to class IV effects, bepridil also
shows class I effects. The substance is active
against both supraventricular and ventricular arrhythmias
, . | [References]
Hollingshead et al. (1992), A review of its pharmacological properties and therapeutic use in stable angina pectoris; Drugs, 44 835
Vatansever et al. (2021), Bepridil is potent against SARS-CoV-2 in vitro; Proc. Natl. Acad. Sci USA, 118 e2012201118
Johansen et al. (2015), A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity; Sci. Transl. Med., 7 290ra89
DeWald et al. (2018), The calcium channel blocker bepridil demonstrates efficacy in the murine model of marburg virus disease; J. Infect. Dis., 218(suppl 5) S588 |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|