ZLc-002 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: ZLc-002 | CAS No.: 1446971-41-0 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | ZLc-002 |
| Description | ZLc-002 is a selective small-molecule inhibitor of nNOS-Capon coupling. ZLc-002 suppresses inflammatory nociception and chemotherapy-induced neuropathic pain. ZLc-002 can be used in anxiety disorder and inflammation research[1] [2] [3]. |
| In vitro | ZLc-002 (1 μM; 24 h) demonstrates inhibitory activity of nNOS-CAPON in cultured hippocampal neurons from ICR mice, as shown in a Cell Viability Assay [3]. |
| In vivo | ZLc-002 demonstrates therapeutic efficacy across several models of disease. At a dosage of 30 mg/kg administered intraperitoneally from days 4 to 46 post-stroke, it significantly improves motor function in transient middle cerebral artery occlusion (tMCAO) mice, indicating its potential for enhancing recovery from stroke-related motor deficits [1]. Moreover, when administered at 40 mg/kg intravenously for seven consecutive days in adult male ICR mice exposed to chronic mild stress (CMS), ZLc-002 alleviates CMS-induced anxiety-related behaviors, evidencing its anxiolytic effects [2]. Additionally, a precise hippocampal injection of 10 μM (1 μL) daily over a week in mice subjected to corticosterone (CORT) reveals a marked improvement in managing CORT-induced anxiety-related behaviors, showcasing its versatility in addressing anxiety disorders induced by chronic stressors [2]. |
| Storage | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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