Product Details
| Product Name:
PH-002 |
CAS No.:
1311174-68-1 |
| Purity:
99.08% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | PH-002 |
| Description | PH-002, an inhibitor targeting the intramolecular domain interaction of apolipoprotein (apo) E4 in neuronal cells, additionally enhances mitochondrial motility and promotes neurite outgrowth, thereby countering related impairments. |
| In vitro | PH-002 inhibits intramolecular domain interaction of apolipoprotein (apo) E4 in neuronal cells (IC50: 116 nM in FRET) [1]. |
| In vivo | PH-002 (100 nM) promotes dendritic spine development in primary neurons from NSE-apoE4 transgenic mice to levels similar to those in NSE-apoE3 neurons (apoE3-expressing primary neurons treated with PH-002 show results comparable to untreated neurons). Additionally, PH-002 enhances COX1 levels in primary neurons from the NSE-apoE4 transgenic mouse cortex and hippocampus, increasing COX1 by ~60% after 4 days of treatment at 200 nM [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 75 mg/mL (152.57 mM)
|
| Keywords | PH-002 | inhibit | Inhibitor | PH002 | PH 002 |
| Related Compound Libraries | Bioactive Compound Library | Inhibitor Library | NO PAINS Compound Library | PPI Inhibitor Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
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Suppliers |
Update time |
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$2500.00/100mg |
VIP3Y
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TargetMol Chemicals Inc.
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2024-11-07 |
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$1980.00/50mg |
VIP1Y
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TargetMol Chemicals Inc.
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2024-11-19 |
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$0.00/1g |
VIP4Y
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XIAMEN SINOPEG BIOTECH CO., LTD.
|
2024-07-30 |
United States