Product Details
| Product Name:
VT107 |
CAS No.:
2417718-63-7 |
| Purity:
99.73% |
Supply Ability:
10g |
| Release date:
2024/11/17 |
Product Introduction
Bioactivity
| 名稱 | VT107 |
| 描述 | VT107 is a potent pan-TEAD autopalmitoylation inhibitor. VT-107 can be used in cancer therapy research.[1] |
| 體外活性 | METHODS: HEK293T cells were treated with 3 μmol/L VT107 for 20 h. After incubation of cells with compounds and alkyne palmitate overnight, the relevant TEAD proteins were immunoprecipitated using specific TEAD antibodies, followed by click chemistry and streptavidin western blot analysis to examine the effects of these compounds on the palmitoylation of endogenous TEAD1, TEAD3, and TEAD4 proteins.
RESULTS VT107 effectively blocked the palmitoylation of endogenous TEAD1 and TEAD3 proteins, and also effectively blocked the palmitoylation of endogenous TEAD4 protein. In addition, VT107 showed a strong inhibitory effect on the proliferation of NF2 mutant/deficient cell lines. [1] |
| 體內(nèi)活性 | METHODS: VT107 was administered intravenously or orally at a dose of 10 mg/kg. Blood was drawn from the saphenous vein at designated time points. Compounds were quantified by LC/MS-MS using a QTRAP 6500
RESULTS The bioavailability of VT107 was 55%. The half-life after intravenous administration was 2.7 hours. [1] |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (114.83 mM), Sonication is recommended.
|
| 關(guān)鍵字 | VT107 | VT 107 | VT-107 |
| 相關(guān)產(chǎn)品 | AICAR | MY-1076 | YAP-TEAD-IN-1 acetate | YAP-TEAD-IN-3 | DC-TEADin02 | Verteporfin | Lats-IN-1 | VT103 | ML-7 hydrochloride | PY-60 | VT104 | MYF-01-37 |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 抑制劑庫(kù) | 已知活性化合物庫(kù) | 抗癌化合物庫(kù) | 抗癌活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States