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Postion:Product Catalog >UCB-9260
UCB-9260
  • UCB-9260

UCB-9260 NEW

Price $98 $243 $405
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: UCB-9260 CAS No.: 1515888-53-5
Purity: 98.39% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameUCB-9260
DescriptionUCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.
In vitroIn Hek-293 cells, UCB-9260 (0-10 μM)?inhibits NF-κB with a geometric mean IC50?of 202?nM after TNF (10?pM) stimulation. UCB-9260?inhibits TNF-dependent cytotoxicity with a geometric mean IC50?of 116?nM and a geometric mean IC50?of 120?nM, using human and mouse TNF, respectively.
In vivoUCB-9260 (150?mg/kg; p.o.) treatment twice daily?for 7 days shows a significant reduction of the clinical score. In adult male Balb/c mice, UCB-9260?(10-300?mg/kg; p.o.) dose-dependently inhibits human and mouse TNF-induced neutrophil recruitment to the peritoneal compartment.
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 4.23 mg/mL (10 mM), Sonication is recommended.
Keywordscytotoxicity | asymmetric | trimer | Inhibitor | neutrophil | autoimmune | UCB9260 | Tumor Necrosis Factor Receptor | TNFR | rheumatoid | UCB 9260 | UCB-9260 | arthritis | inhibit | TNF Receptor | cytokine | selective
Inhibitors RelatedCepharanthine | Acetylcysteine | Acefylline | Glucosamine | Thalidomide | Taurochenodeoxycholic Acid | Apremilast | Pomalidomide | Bergenin | Lenalidomide | Fisetin | Linalool
Related Compound LibrariesApoptosis Compound Library | Bioactive Compound Library | Cytokine Inhibitor Library | Inhibitor Library | NO PAINS Compound Library | Immuno-Oncology Compound Library | Orally Active Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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Recommended supplier

Product name Price   Suppliers Update time
$1520.00/25mg
VIP1Y
TargetMol Chemicals Inc.
2024-10-23
$98.00/1mg
VIP3Y
TargetMol Chemicals Inc.
2024-11-19
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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