TDI-11055 NEW
| Price | $130 | $290 | $480 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-07 |
Product Details
| Product Name: TDI-11055 | Supply Ability: 10g |
| Release date: 2024/11/07 |
Product Introduction
Bioactivity
| 名稱 | TDI-11055 |
| 描述 | TDI-11055 is an orally available inhibitor of chromatin reader 11-19 leukemia (ENL) that works by blocking the interaction of its YEATS domain with acylated histones. TDI-11055 can be used to study acute myeloid leukemia (AML). |
| 體外活性 | Time-resolved fluorescence energy transfer (TR-FRET) assays were used to measure the inhibitory effects of TDI-11055 on the interactions between different YEATS domains and acylated histone peptides. TDI-11055 retained potency and selectivity for the YEATS domains of ENL (IC50 = 0.05 μmol/L) and AF9 (IC50 = 0.07 μmol/L) but showed no inhibition of the YEATS domains of GAS41 and YEATS2. [2] |
| 體內(nèi)活性 | Mouse xenograft model using MV4;11 cells subcutaneously implanted into BALB/c nude mice. After tumors reached approximately 300 to 400 mm3, treatment with TDI-11055 [100 or 200 mg/kg, per os (p.o.), b.i.d.] or vehicle was initiated and continued for 8 consecutive days. Dosing with TDI-11055 twice daily resulted in significant inhibition of tumor growth over 8 days of treatment with no overt effect on body weight. Gene expression analysis of tumors at the end of treatment revealed a substantial reduction in the expression of key ENL target genes (HOXA9, MYC, MEIS1, and MYB) in tumors in the TDI-11055–-treated group compared with vehicle controls. [2] |
| 存儲(chǔ)條件 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 80 mg/mL (205.94 mM), Sonication is recommended. |
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Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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