Tandospirone citrate is a third-generation novel anti-anxiety medication that primarily acts on the limbic system of the brain. It exhibits high selectivity for the 5-HT1A receptors and exerts anxiolytic and antidepressant effects by inhibiting excessive 5-HT neural impulses. It does not cause dependence, sedation, muscle relaxation, or motor inhibition, making it clinically advantageous. It is suitable for treating anxiety states caused by various neuroses, such as generalized anxiety disorder, as well as anxiety states accompanying primary hypertension, peptic ulcer, and other somatic diseases.

Biological Activity:

Tandospirone citrate (SM-3997 citrate) is an effective, selective 5-HT1A receptor agonist (Ki = 27nM). It exhibits high selectivity for SR-2, SR-1C, α1, α2, D1, and D2 receptors (Ki values ranging from 1300-41000nM).