Product Details
Product Name:
SMER3 |
CAS No.:
67200-34-4 |
Purity:
98.35% |
Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
Name | SMER3 |
Description | SMER3 is an inhibitor of the Skp1-Cullin-F-box (SCF)(Met30) ubiquitin ligase, a member of the SCF E3-ligase family, which regulates diverse cellular processes including transcription, cell-cycle control and immune response. |
In vitro | SMER 3 and rapidly increased PFKFB3 protein levels. Accordingly, ubiquitin-bound PFKFB3 was lower in E2- or G1-treated HUVECs. Both agents increased deubiquitinase USP19 levels through GPER signaling[1]. |
In vivo | SMER 3 diminishes binding of the F-box subunit Met30 to the SCF core complex in vivo and show evidence for SMER 3 directly binding to Met30[2]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 8 mg/mL (35.69 mM)
|
Keywords | SMER-3 | Ubiquitin activating enzyme | SCF | E1/E2/E3 Enzyme | anticancer | MET | SMER3 | Skp1 | E1 activating enzyme | ligase | Inhibitor | Cullin | E2 conjugating enzyme | ubiquitin | Ubiquitin conjugating enzyme | Ubiquitin ligase | E3 ligating enzyme | inhibit |
Inhibitors Related | Lenalidomide-Br | Thalidomide | Lenalidomide |
Related Compound Libraries | Bioactive Compound Library | HIF-1 Signaling Pathway Compound Library | Inhibitor Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
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$/ |
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Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |