Bay 41-4109 racemate NEW
| Price | $34 | $55 | $97 |
| Package | 2mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Bay 41-4109 racemate | CAS No.: 298708-79-9 |
| Purity: 98.48% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Bay 41-4109 racemate |
| Description | BAY 41-4109 racemate is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM. |
| Cell Research | Cellular metabolism is evaluated by MTT colorimetry. HepG2.2.15 cells are plated at a density of 2 × 103 cells per well in 96-well plates. After 8 d of treatment with different concentrations of each antiviral compound, 20 μL of MTT solution (5 g/L) are added to each well and incubated at 37°C for 4 h. Next, 150 μL of DMSO is added and stirred for 10 min to dissolve the crystals. Absorbance values are recorded at 490 nm by using an ELISA reader. The MTT values are calculated using the curve regression equation[3]. |
| In vitro | BAY 41-4109 accelerates and misdirects capsid assembly in vitro and stabilizes preformed capsids up to a ratio of one inhibitor molecule per two dimers[2]. It inhibits HBV DNA release and cytoplasmic HBcAg levels equally effectively, with IC50s of 32.6 and 132 nM in HepG2.2.15 cells, respectively, indicating dose-dependent anti-HBV mechanisms associated with HBcAg inhibition[3]. |
| In vivo | BAY 41-4109 effectively diminishes viral DNA levels in both the liver and plasma in a dose-dependent fashion, showing efficacy on par with 3TC. It also decreases the hepatitis B virus core antigen (HBcAg) in the livers of HBV-transgenic mice. Pharmacokinetic evaluations reveal its rapid absorption and a bioavailability rate of 30%, with dose-proportional plasma concentrations observed, reaching approximately 60% in rats and dogs[1]. Furthermore, BAY41-4109 hampers virus production in vivo by targeting the viral capsid, demonstrating its mechanism of action[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (126.34 mM) |
| Keywords | HBV | Bay 41 4109 racemate | inhibit | Bay 41-4109 racemate | Hepatitis B virus | Bay 414109 racemate | Inhibitor | Bay 41-4109 |
| Inhibitors Related | Doxorubicin hydrochloride | Osthole | RO8191 | Tenofovir Disoproxil Fumarate | Thiamine hydrochloride | 4,5-Dicaffeoylquinic acid | 4-Hydroxyacetophenone | Telbivudine | Tenofovir | Bifendate |
| Related Compound Libraries | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | Anti-Viral Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Anti-COVID-19 Compound Library | Anti-Infection Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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