RG7800 tetrahydrochloride NEW
Price | $42 |
Package | 2mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-19 |
Product Details
Product Name: RG7800 tetrahydrochloride | Supply Ability: 10g |
Release date: 2024/11/19 |
Product Introduction
Bioactivity
Name | RG7800 tetrahydrochloride |
Description | RG7800 hydrochloride is an orally active SMN2 splicing modulator with EC50 values of 23 nM for splicing and 87 nM for SMN protein production, holding promise as a therapeutic agent for [spinal muscular atrophy]. |
In vitro | RG7800 hydrochloride is an orally active SMN2 splicing modulator with EC50s of 23 nM for SMN2 splicing and 87 nM for SMN protein production. It is the first small molecule SMN2 splicing modifier to advance into human clinical trials [1]. |
In vivo | RG7800 exhibits a favorable metabolism and pharmacokinetic (DMPK) profile in both rats and cynomolgus monkeys, paired with good oral bioavailability. Administered at doses of 1, 3, and 10 mg/kg orally, RG7800 dose-dependently increases SMN protein levels in both the central nervous system and peripheral tissues of Δ7 mice [1]. |
Storage | Shipping with blue ice. |
Keywords | RG 7800 | RO 6885247 Tetrahydrochloride | RO-6885247 Tetrahydrochloride | RG-7800 Tetrahydrochloride | RO6885247 | RO-6885247 | RO 6885247 | RG7800 | RG 7800 Tetrahydrochloride | RO6885247 Tetrahydrochloride | RG-7800 | RG7800 Tetrahydrochloride |
Inhibitors Related | Rifampicin | 5-Fluorouracil | Ribavirin | Guanidine hydrochloride | 2,4-D | Resveratrol | Acyclovir | Thymidine | Temozolomide | Folic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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