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Postion:Product Catalog >RG7800 tetrahydrochloride
RG7800 tetrahydrochloride
  • RG7800 tetrahydrochloride

RG7800 tetrahydrochloride NEW

Price $42
Package 2mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: RG7800 tetrahydrochloride Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameRG7800 tetrahydrochloride
DescriptionRG7800 hydrochloride is an orally active SMN2 splicing modulator with EC50 values of 23 nM for splicing and 87 nM for SMN protein production, holding promise as a therapeutic agent for [spinal muscular atrophy].
In vitroRG7800 hydrochloride is an orally active SMN2 splicing modulator with EC50s of 23 nM for SMN2 splicing and 87 nM for SMN protein production. It is the first small molecule SMN2 splicing modifier to advance into human clinical trials [1].
In vivoRG7800 exhibits a favorable metabolism and pharmacokinetic (DMPK) profile in both rats and cynomolgus monkeys, paired with good oral bioavailability. Administered at doses of 1, 3, and 10 mg/kg orally, RG7800 dose-dependently increases SMN protein levels in both the central nervous system and peripheral tissues of Δ7 mice [1].
StorageShipping with blue ice.
KeywordsRG 7800 | RO 6885247 Tetrahydrochloride | RO-6885247 Tetrahydrochloride | RG-7800 Tetrahydrochloride | RO6885247 | RO-6885247 | RO 6885247 | RG7800 | RG 7800 Tetrahydrochloride | RO6885247 Tetrahydrochloride | RG-7800 | RG7800 Tetrahydrochloride
Inhibitors RelatedRifampicin | 5-Fluorouracil | Ribavirin | Guanidine hydrochloride | 2,4-D | Resveratrol | Acyclovir | Thymidine | Temozolomide | Folic acid

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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