Punicalagin NEW
| Price | $130 | $198 |
| Package | 20mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Punicalagin | CAS No.: 65995-63-3 |
| Purity: 99.7% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Punicalagin |
| Description | Punicalagin is a major ellagitannin found in pomegranates that is reported to produce antioxidant, anti-inflammatory, and anticancer effects. It has been shown to prevent high-fat diet-induced obesity-associated accumulation of cardiac triglyceride and cholesterol, as well as myocardial damage, via AMPK-mediated modulation of mitochondria and phase II enzymes. |
| In vitro | METHODS: Human cervical cells ME-180 were treated with Punicalagin (10-100 μM) for 24 h. Cell viability was measured by MTT assay. RESULTS: Punicalagin showed significant concentration-dependent cytotoxicity against ME-180 cells. The cell viability of Punicalagin-treated cells was reduced by approximately 80% compared to control cells. [1] METHODS: Human cervical cancer cells, the HeLa, were treated with Punicalagin (25-100 μM) for 36 h. The cell cycle was detected by Flow cytometry. RESULTS: The number of G1-phase cells increased significantly after 36 h of Punicalagin treatment. [2] |
| In vivo | METHODS: To study the effects on MTX-induced hepatotoxicity in mice, Punicalagin (25-50 mg/kg, 0.5% CMC) was administered orally to Swiss albino mice once daily for ten days, followed by a single dose of MTX (20 mg/kg) injected intraperitoneally on the seventh day. RESULTS: Punicalagin significantly attenuated MTX-induced elevation of serum aminotransferases, ALP, and LDH, as well as hepatic oxidative stress measures, and enhanced hepatic antioxidant defense. In MTX-induced mouse liver, Punicalagin inhibited oxidative damage, inflammation and apoptosis and upregulated Nrf2. [3] |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 55 mg/mL (50.7 mM) |
| Keywords | SARS-CoV | Punicalagin | Pomegranate | anti-inflammatory | SARS coronavirus | Antioxidant | Hepatitis B virus | inhibit | anticancer | ingredient | HBV | polyphenol | Inhibitor |
| Inhibitors Related | Hydroxychloroquine | Chloroquine phosphate | Tenofovir |
| Related Compound Libraries | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Anti-Cancer Clinical Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Anti-Viral Compound Library | Inhibitor Library | Anti-Aging Compound Library | Anti-infective Natural Product Library | Anti-virus Traditional Chinese Medicine Monomer Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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