Procyanidin A1 NEW
| Price | $80 | $163 | $263 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Procyanidin A1 | CAS No.: 103883-03-0 |
| Purity: 99.23% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Procyanidin A1 |
| Description | Procyanidin A1 (Proanthocyanidin A1) has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or Ca2+; influx from an internal store in RBL-2H3 cells. |
| In vitro | We found that a peanut-skin extract (PSE) inhibits the degranulation induced by antigen stimulation of rat basophilic leukemia (RBL-2H3) cells. A low-molecular-weight fraction from PSE, PSEL, also had inhibitory activity against allergic degranulation. A main polyphenol in PSEL was purified by gel chromatography and fractionated by YMC-gel ODS-AQ 120S50 column. Electrospray ionization mass spectrometry (ESI-MS) analysis of the purified polyphenol gave m/z 599 [M+Na]?. Based on the results of 1H-NMR, 13C-NMR spectra, and optical rotation analysis, the polyphenol was identified as Procyanidin A1. It inhibited the degranulation caused by antigen stimulation at the IC50 of 20.3 μM. Phorbol-12-myristate-13-acetate (PMA) and 2,5,-di(tert-butyl)-1,4-hydroquinone (DTBHQ)-induced processes of degranulation were also inhibited by Procyanidin A1[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 55 mg/mL (95.4 mM) |
| Keywords | Inhibitor | Proanthocyanidin A 1 | Procyanidin A 1 | Protein kinase C | inhibit | PKC | Procyanidin A1 | Proanthocyanidin A-1 | Procyanidin A-1 |
| Inhibitors Related | Nisoldipine | Nimodipine | Diltiazem hydrochloride | Levetiracetam | L-Ascorbic acid | α-Vitamin E | Taurine | Ethyl cinnamate | 1-Octanol | 2-Nitrobenzoic acid | Methyl homoveratrate | Otilonium bromide |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Flavonoid Natural Product Library | Pain-Related Compound Library | Bioactive Compound Library | Kinase Inhibitor Library | Selected Plant-Sourced Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Ancient Chinese Classical Formulas Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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