NLRP3-IN-16 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: NLRP3-IN-16 | CAS No.: 2906872-59-9 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | NLRP3-IN-16 |
| Description | NLRP3-IN-16 is a potent, selective inhibitor of the NLRP3 inflammasome, effectively reducing IL-1β release with an IC50 of 0.065 μM, and is primarily utilized in inflammation research [1]. |
| In vitro | NLRP3-IN-16 (Compound 12d) inhibits the release of IL-1β with an IC50 of 0.065 μM, as measured by ELISA [1]. At a concentration of 2 μM, for 3 hours, it suppresses the secretion of IL-1β (p17) and caspase-1 (p20) in mouse peritoneal macrophages (PM) [1]. Additionally, NLRP3-IN-16 impedes the formation of the NLRP3 inflammasome complex by inhibiting ASC oligomerization [1]. It exhibits metabolic stability in human and mouse liver microsomes, with a half-life (T 1/2) of 223.5 minutes and an intrinsic clearance (Cl int) of 6.2 μL/min/mg [1]. |
| In vivo | NLRP3-IN-16 (Compound 5j) exhibited anti-inflammatory effects in a sepsis mouse model when administered at a dose of 50 mg/kg intraperitoneally [1]. |
| Storage | Shipping with blue ice. |
| Inhibitors Related | Stavudine | Dapansutrile | NOD-IN-1 | MCC950 sodium | Muscone | NLRP3-IN-2 | Nigericin sodium salt | Troxerutin | INF39 | JC2-11 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
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