NLRP3-IN-17 NEW
| Price | $140 |
| Package | 2mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: NLRP3-IN-17 | CAS No.: 2254432-75-0 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | NLRP3-IN-17 |
| Description | NLRP3-IN-17 is a potent, selective, and orally active inhibitor of the NLRP3 inflammasome with an IC50 of 7 nM, effectively inhibiting NLRP3-dependent IL-1β secretion in mice, making it valuable for chronic inflammatory disease research [1]. |
| In vivo | NLRP3-IN-17 (compound 15) administered orally at 3 mg/kg demonstrated favorable pharmacokinetic (PK) data, with an area under the curve (AUC), half-life (t 1/2), and bioavailability (F%) of 4.2 μg.h/mL, 2.91 h, and 56%, respectively [1]. At a single oral dose of 10 mg/kg, it significantly inhibited NLRP3-dependent IL-1β secretion, reducing IL-1β levels by 44% in an acute in vivo LPS+ATP stimulation model in female C57BL/6 mice [1]. |
| Storage | Shipping with blue ice. |
| Inhibitors Related | Stavudine | Dapansutrile | NOD-IN-1 | CY-09 | MCC950 sodium | Muscone | NLRP3-IN-2 | Troxerutin | INF39 | JC2-11 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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