Product Details
| Product Name:
MT-DADMe-ImmA |
CAS No.:
653592-04-2 |
| Purity:
99.53% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | MT-DADMe-ImmA |
| Description | MT-DADMe-ImmA (MTDIA) is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP, Ki: 90 pM). |
| Cell Research | Cell viability is evaluated using the Alamar Blue assay. Cells are seeded onto 96-well plates at a density of 10^4 cells/well and incubated with increasing concentrations of MT-DADMe-ImmA (100 pM to 100 μM) for 4 days at fixed MTA concentrations (0, 5, 10, and 20 μM) [2]. |
| Animal Research | Tumors were established in mice for 5 days prior to oral or intraperitoneal treatments with MT-DADMe-ImmA. Mice are treated with an oral dose of 21 mg/kg or an intraperitoneal dose of 5 mg/kg/day MT-DADMe-ImmA [2]. |
| In vitro | Treatment of cultured cells with MTA and MT-DADMe-ImmA inhibit MTAP, increase cellular MTA concentrations, decrease polyamines, and induce apoptosis in FaDu and Cal27, two head and neck squamous cell carcinoma cell lines. MT-DADMe-ImmA alone does not induce apoptosis in any cell line [2]. |
| In vivo | MTAP activity slowly returns, giving a biological half-life for the action of oral MT-DADMe-ImmA of 6.3 days. The time-dependent growth of FaDu tumors in immunodeficient mice is suppressed by oral or intraperitoneal treatment with MT-DADMe-ImmA [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (170.42 mM)
|
| Keywords | MTDADMeImmA | inhibit | MT-DADMe-ImmA | MT DADMe ImmA | Inhibitor |
| Related Compound Libraries | Bioactive Compound Library | Inhibitor Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$30.00/1Box |
|
Hebei Weimiao Import and Export Trade Co., Ltd.
|
2024-11-21 |
|
|
$58.00/1mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-19 |
|
|
$0.00/1mg |
VIP4Y
|
WUHAN FORTUNA CHEMICAL CO., LTD
|
2021-08-26 |
United States