天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
+1 (818) 612-2111
Inquriy
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >API>Antiparasitic drugs>Antifilarial and Leishmaniasis Drugs>Ivermectin
Ivermectin
  • Ivermectin
  • Ivermectin
  • Ivermectin

Ivermectin

Price $10
Package 1kg
Min. Order: 1kg
Supply Ability: Ex 20 tons
Update Time: 2022-10-14

Product Details

Product Name: Ivermectin CAS No.: 70288-86-7
EC-No.: 274-536-0 Min. Order: 1kg
Purity: 99% Supply Ability: Ex 20 tons
Release date: 2022/10/14

WHATSAPP:+8615383008051  WICKR ME: CHRISTINE85

email:109@hebeianda.cn


Use of Ivermectin


Ivermectin is a widely used antiparasitic agent in human and veterinary medicine. It is a positive allosteric effector of P2X4 and the α7 neuronal nicotinic acetylcholine receptor (nAChRs).

Names

Nameivermectin
SynonymMore Synonyms

 Ivermectin Biological Activity

DescriptionIvermectin is a widely used antiparasitic agent in human and veterinary medicine. It is a positive allosteric effector of P2X4 and the α7 neuronal nicotinic acetylcholine receptor (nAChRs).
Related Catalog
Signaling Pathways >> Autophagy >> Autophagy
Signaling Pathways >> Autophagy >> Mitophagy
Signaling Pathways >> Anti-infection >> Parasite
Research Areas >> Infection
In VitroIvermectin (IVM) is a specific positive allosteric effector of heterologously expressed P2X4 and possibly of heteromeric P2X4/ P2X6 channels. In the submicromolar range (EC50=250 nM) the action of IVM is rapid and reversible, resulting in increased amplitude and slowed deactivation of P2X4 channel currents evoked by ATP. IVM also markedly increases the potency of ATP and that of the normally low-potency agonist a,b-methylene-ATP in a use- and voltage-independent manner without changing the ion selectivity of P2X4 channels[1]. IVM activates glutamate-gated chloride channels in the nerves and muscles of the parasite, leading to membrane hyperpolarization and muscle paralysis. The major mode of action of IVM is most likely the disruption of ingestive activity of the parasite, resulting in starvation[2]. Preapplication of ivermectin, in the micromolar range, strongly enhances the subsequent acetylcholine-evoked current of the neuronal chick or human α7 nicotinic acetylcholine receptors reconstituted in Xenopus laevis oocytes and K-28 cells[3]. Ivermectin activates the rat recombinant α1β2γ2s GABAA receptor. Activation of the channel with 10 mM GABA results in currents rising within 1 ms to their maximal amplitudes. The EC50 value for GABA is 7.5 μM[4].
Solvent
In Vitro:

DMSO : ≥ 50 mg/mL (57.14 mM)

H2O : < 0.1 mg/mL (insoluble)

* "≥" means soluble, but saturation unknown.





Company Profile Introduction

You may like

Recommended supplier

Product name Price   Suppliers Update time
$30.00/100g
VIP1Y
Shenzhen Aoxi Technology Co., Ltd.
 2025-03-24
$120.00/1kg
VIP1Y
Hebei Junhua Import and Export Co., LTD
 2025-03-21
$0.00/1KG
VIP4Y
Wuhan Biocar Pharmacy CO.,Ltd.
 2025-03-06
$100.00/1KG
VIP1Y
Hebei Yiduo Import and Export Co., Ltd.
 2025-02-28
$380.00/1kg
VIP1Y
Guangdong Junhua Chemical Co., Ltd
 2024-12-24
$0.00/1Box
VIP1Y
American HealthyMorph LLC
 2024-12-20
$53.00/500mg
VIP5Y
TargetMol Chemicals Inc.
2024-11-19
$53.00/500mg
VIP3Y
TargetMol Chemicals Inc.
2024-11-19
$10.00/25kg
VIP6Y
Hebei Chuanghai Biotechnology Co., Ltd
 2024-10-24
$200.00/1kg
VIP4Y
Hebei Lingding Biotechnology Co., Ltd.
 2024-10-24
  • Since: 2022-02-24
  • Address: 3-1-1005, Federal Business Plaza, 166 Yuhua West Road, Qiaoxi District, Shijiazhuang City, Hebei Pro
INQUIRY

+86-19831998802
106@hebeianda.cn